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【结 构 式】 
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【分子编号】13039 【品名】1-[6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl]-1-ethanone 【CA登记号】 |
【 分 子 式 】C13H17NO3 【 分 子 量 】235.28292 【元素组成】C 66.36% H 7.28% N 5.95% O 20.4% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The condensation of 2-amino-4,5-dimethoxybenzonitrile (I) with 2-acetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (II) by means of POCl3 and dimethylacetamide in refluxing CHCl3 gives 2-[1-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethylideneamino]-4,5-dimethoxybenzonitrile (III), which is then cyclized with lithium diisopropylamide in THF at -70 C or with ZnCl2 in refluxing dimethylacetamide.
| 【1】 Campbell, S.F.; Hardstone, J.D. (Pfizer Inc.); 2-Substd.-4-amino-6,7-dimethoxyquinolines. EP 0100200 . |
| 【2】 Hardstone, J.D.; Palmer, M.J. A.; Campbell, S.F.; A convenient synthesis of 2,4-diaminoquinoline derivatives. Tetrahedron Lett 1984, 25, 42, 4813. |
| 【3】 Pento, J.T.; Abanoquil Mesylate. Drugs Fut 1992, 17, 11, 983. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13038 | 2-Amino-4,5-dimethoxybenzonitrile | 26961-27-3 | C9H10N2O2 | 详情 | 详情 |
| (II) | 13039 | 1-[6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl]-1-ethanone | C13H17NO3 | 详情 | 详情 | |
| (III) | 13040 | 2-([(E)-1-[6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl]ethylidene]amino)-4,5-dimethoxybenzonitrile | C22H25N3O4 | 详情 | 详情 |
Extended Information