【结 构 式】 |
【分子编号】12952 【品名】2-Lithio-thiophenol lithium salt 【CA登记号】 |
【 分 子 式 】C6H4Li2S 【 分 子 量 】122.04576 【元素组成】C 59.05% H 3.3% Li 11.37% S 26.27% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)A new efficient synthesis of 2-acetylbenzothiophene (I), the key starting material for the previously reported synthesis of zileuton, has been described: Thiophenol (II) is dilithiated with butyllithium and tetramethylethylenediamine in cyclohexane to compound (III), which is then cyclized by successive treatments with DMF and chloroacetone (IV) in THF to afford (I) in high yield.
【1】 Brooks, D.W.; Basha, A.; Synthesis of the 5-lipoxygenase inhibitor zileuton from thiophenol. J Org Chem 1993, 58, 5, 1293. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
15288 | 1-Chloroacetone; Chloroacetone | 78-95-5 | C3H5ClO | 详情 | 详情 | |
(I) | 12947 | 1-(1-Benzothiophen-2-yl)-1-ethanone | 22720-75-8 | C10H8OS | 详情 | 详情 |
(II) | 12951 | Benzenethiol; Phenylmercaptan; Phenylhydrosulfide | 108-98-5 | C6H6S | 详情 | 详情 |
(III) | 12952 | 2-Lithio-thiophenol lithium salt | C6H4Li2S | 详情 | 详情 |
Extended Information