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【结 构 式】 
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【分子编号】12935 【品名】N-[3-(2-Chlorobenzoyl)-5-(4-isobutylphenethyl)-2-thienyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide 【CA登记号】 |
【 分 子 式 】C34H31ClN2O4S 【 分 子 量 】599.14992 【元素组成】C 68.16% H 5.22% Cl 5.92% N 4.68% O 10.68% S 5.35% |
合成路线1
该中间体在本合成路线中的序号：(V)A new synthesis of Y-24180 has been published: The reaction of 2-(2-chlorobenzoyl)acetonitrile (I) with 4-(4-isobutylphenyl)butyraldehyde (II) and sulfur by means of triethylamine in DMF gives the benzoylthiophene (III), which is condensed with 2-phthalimidopropionyl chloride (IV) yielding the propionamidothiophene (V). Elimination of the phthalimido group of (V) first with hydrazine and then with HCl affords the alanylaminothiophene (VI), which is cyclized by means of acetic acid giving 5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-3-methyl-2,3-dihydro-1 H-thieno[3,2-f][1,4]diazepin-2-one (VII). The reaction of (VII) with P2S5 yields the corresponding thioketone (VIII), which by reaction with hydrazine is converted into the hydrazone (IX). Finally, this compound is cyclized with triethyl orthoacetate (X).
| 【1】 Kawakami, Y.; Moriwaki, M.; Kitani, H.; Kagoshima, M.; Abe, M.; Tahara, T.; Terasawa, M.; Yuasa, S.; Structural optimization of 4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1, 2,4]triazolo[4,3-a][1,4]diazepines as antagonists for platelet activating factor: Pharmacological contribution of substituents at the 2- and 6-positions of a condensed ring system. Eur J Med Chem 1996, 31, 9, 683. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12923 | 3-(2-Chlorophenyl)-3-oxopropanenitrile | 40018-25-5 | C9H6ClNO | 详情 | 详情 |
| (II) | 12924 | 4-(4-Isobutylphenyl)butanal | C14H20O | 详情 | 详情 | |
| (III) | 12925 | [2-Amino-5-(4-isobutylphenethyl)-3-thienyl](2-chlorophenyl)methanone | C23H24ClNOS | 详情 | 详情 | |
| (IV) | 12934 | 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl chloride | C11H8ClNO3 | 详情 | 详情 | |
| (V) | 12935 | N-[3-(2-Chlorobenzoyl)-5-(4-isobutylphenethyl)-2-thienyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide | C34H31ClN2O4S | 详情 | 详情 | |
| (VI) | 12928 | 2-Amino-N-[3-(2-chlorobenzoyl)-5-(4-isobutylphenethyl)-2-thienyl]propanamide | C26H29ClN2O2S | 详情 | 详情 | |
| (VII) | 12929 | 5-(2-Chlorophenyl)-7-(4-isobutylphenethyl)-3-methyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-one | C26H27ClN2OS | 详情 | 详情 | |
| (VIII) | 12930 | 5-(2-Chlorophenyl)-7-(4-isobutylphenethyl)-3-methyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepine-2-thione | C26H27ClN2S2 | 详情 | 详情 | |
| (IX) | 12939 | 5-(2-Chlorophenyl)-7-(4-isobutylphenethyl)-3-methyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-one hydrazone | C26H29ClN4S | 详情 | 详情 | |
| (X) | 12940 | 1,1-Diethoxyethyl ethyl ether; 1,1,1-Triethoxyethane; Triethyl orthoacetate | 78-39-7 | C8H18O3 | 详情 | 详情 |