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【结 构 式】

【分子编号】12833

【品名】(2-Methyl-1H-benzimidazol-5-yl)(phenyl)methanol

【CA登记号】

【 分 子 式 】C15H14N2O

【 分 子 量 】238.28904

【元素组成】C 75.61% H 5.92% N 11.76% O 6.71%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The cyclization of 3,4-diaminobenzophenone (I) with acetylimidic acid ethyl ester (II) in refluxing methanol gives 5-benzoyl-2-methylbenzimidazole (III), which is reduced with NaBH4 in methanol yielding 5-(alpha-hydroxybenzyl)-2-methylbenzimidazole (IV). Finally, this compound is condensed with imidazole (V) in refluxing acetonitrile.

1 Raeymaekers, A.H.M.; Freyne, E.J.E.; Sanz, G.C. (Janssen Pharmaceutica NV); Novel (1H-imidazol-1-ylmethyl) substd. benzimidazole derivs. AU 8778385; EP 0260744; JP 1989085975; US 4859684 .
2 Castaner, J.; Prous, J.; Irtemazole. Drugs Fut 1991, 16, 12, 1094.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12830 (3,4-Diaminophenyl)phenylmethanone; 3,4-Diaminobenzophenone 39070-63-8 C13H12N2O 详情 详情
(II) 12831 ethyl ethanimidoate 1000-84-6 C4H9NO 详情 详情
(III) 12832 (2-Methyl-1H-benzimidazol-5-yl)(phenyl)methanone C15H12N2O 详情 详情
(IV) 12833 (2-Methyl-1H-benzimidazol-5-yl)(phenyl)methanol C15H14N2O 详情 详情
(V) 10255 Imidazole; 1H-Imidazole 288-32-4 C3H4N2 详情 详情
Extended Information