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【结 构 式】 
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【分子编号】12833 【品名】(2-Methyl-1H-benzimidazol-5-yl)(phenyl)methanol 【CA登记号】 |
【 分 子 式 】C15H14N2O 【 分 子 量 】238.28904 【元素组成】C 75.61% H 5.92% N 11.76% O 6.71% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The cyclization of 3,4-diaminobenzophenone (I) with acetylimidic acid ethyl ester (II) in refluxing methanol gives 5-benzoyl-2-methylbenzimidazole (III), which is reduced with NaBH4 in methanol yielding 5-(alpha-hydroxybenzyl)-2-methylbenzimidazole (IV). Finally, this compound is condensed with imidazole (V) in refluxing acetonitrile.
| 【1】 Raeymaekers, A.H.M.; Freyne, E.J.E.; Sanz, G.C. (Janssen Pharmaceutica NV); Novel (1H-imidazol-1-ylmethyl) substd. benzimidazole derivs. AU 8778385; EP 0260744; JP 1989085975; US 4859684 . |
| 【2】 Castaner, J.; Prous, J.; Irtemazole. Drugs Fut 1991, 16, 12, 1094. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12830 | (3,4-Diaminophenyl)phenylmethanone; 3,4-Diaminobenzophenone | 39070-63-8 | C13H12N2O | 详情 | 详情 |
| (II) | 12831 | ethyl ethanimidoate | 1000-84-6 | C4H9NO | 详情 | 详情 |
| (III) | 12832 | (2-Methyl-1H-benzimidazol-5-yl)(phenyl)methanone | C15H12N2O | 详情 | 详情 | |
| (IV) | 12833 | (2-Methyl-1H-benzimidazol-5-yl)(phenyl)methanol | C15H14N2O | 详情 | 详情 | |
| (V) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
Extended Information