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【结 构 式】 
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【分子编号】12697 【品名】(2S)-3-[4-amino-2-oxo-1(2H)-pyrimidinyl]-2-hydroxypropyl hydrogen chloromethylphosphonate 【CA登记号】 |
【 分 子 式 】C8H13ClN3O5P 【 分 子 量 】297.634902 【元素组成】C 32.28% H 4.4% Cl 11.91% N 14.12% O 26.88% P 10.41% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)1) The reaction of 1-[2(S),3-dihydroxypropyl]cytosine (I) with chloromethylphosphoryl dichloride (II) in triethyl phosphate, followed by hydrolysis with boiling water gives the chloromethylphosphonate (III), which is then isomerized with aqueous NaOH at 80 C.
| 【1】 Fromtling, R.A.; Castaner, J.; Cidofovir. Drugs Fut 1996, 21, 10, 1003. |
| 【2】 Holy, A.; Rosenberg, I.; De Clercq, E. (Czech Academy of Sciences; Rega Institute for Medical Research); N-Phosphonylmethoxyalkyl derivs. of pyrimidine and urine bases, methods for their preparation and pharmaceutical compsns. therefrom with antiviral activity. EP 0253412; JP 1988045289; US 5142051; US 5869467 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12695 | 4-Amino-1-[(2S)-2,3-dihydroxypropyl]-2(1H)-pyrimidinone | C7H11N3O3 | 详情 | 详情 | |
| (II) | 12696 | Chloromethylphosphonic dichloride | 1983-26-2 | CH2Cl3OP | 详情 | 详情 |
| (III) | 12697 | (2S)-3-[4-amino-2-oxo-1(2H)-pyrimidinyl]-2-hydroxypropyl hydrogen chloromethylphosphonate | C8H13ClN3O5P | 详情 | 详情 |
Extended Information