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【结 构 式】

【分子编号】12663

【品名】1-Chloro-3-(2-fluoro[1,1'-biphenyl]-4-yl)-2-butanone

【CA登记号】

【 分 子 式 】C16H14ClFO

【 分 子 量 】276.7376632

【元素组成】C 69.44% H 5.1% Cl 12.81% F 6.87% O 5.78%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The reaction of 2-(2-fluorobiphenyl-4-yl)propionic acid (I) with thionyl chloride followed by treatment with tris (trimethylsilyloxy)ethylene gives 3-(2-fluorobiphenyl-4-yl)-1-hydroxy-2-butanone (II), which upon treatment with carbon tetrachloride and triphenylphosphine affords 1-chloro-3-(2-fluorobiphenyl-4-yl)-2-butanone (III). Finally, compound (III) is heated with N-methylthiourea in water.

1 Ozato, Y.; Tamura, N.; Masumori, H.; Yamamoto, M.; Kojima, A.; Nishikakau, F.; Kimura, Y. (Sumitomo Pharmaceuticals Co., Ltd.); Aminazole derivatives and their production and use. EP 0248399; JP 1988152368; JP 1993247014; US 4914112; US 5066666; US 5180731 .
2 Prous, J.; Castaner, J.; Graul, A.; SM-8849. Drugs Fut 1994, 19, 4, 347.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12280 Flurbiprofen; 2-(2-Fluoro[1,1'-biphenyl]-4-yl)propionic acid 5104-49-4 C15H13FO2 详情 详情
(II) 63470 3-(2-fluoro[1,1'-biphenyl]-4-yl)-1-hydroxy-2-butanone C16H15FO2 详情 详情
(III) 12663 1-Chloro-3-(2-fluoro[1,1'-biphenyl]-4-yl)-2-butanone C16H14ClFO 详情 详情
Extended Information