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【结 构 式】

【分子编号】12499

【品名】5-cyano-6-hydroxy-2-pyridinyl benzoate

【CA登记号】

【 分 子 式 】C13H8N2O3

【 分 子 量 】240.2182

【元素组成】C 65% H 3.36% N 11.66% O 19.98%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

By condensation of 3-[3-(chlorocarbonyl)benzoyl]-1-(ethoxymethyl)-5-fluorouracil (I) with 6-benzoyloxy-3-cyano-2-hydroxypyridine (II) by means of triethylamine in refluxing acetonitrile. The starting compounds (I) and (II) are obtained as follows: The reaction of 1-(ethoxymethyl)-5-fluorouracil (III) with isophthaloyl dichloride (IV) by means of triethylamine in refluxing dioxane gives uracil (I). The esterification of 3-cyano-2,6-dihydroxypyridine (V) with benzoyl chloride (VI) by means of triethylamine in dimethylacetamide affords pyridine (II).

1 Fujii, S. (Otsuka Pharmaceutical Co., Ltd.); 5-Fluorouracil derivs., process for their preparation and their use. DE 3709699; FR 2605006; GB 2192880; JP 1988201127; JP 1988301880 .
2 Castaner, J.; Hoshi, A.; Emitefur. Drugs Fut 1993, 18, 5, 418.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12498 3-[[3-(Ethoxymethyl)-5-fluoro-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]carbonyl]benzoyl chloride C15H12ClFN2O5 详情 详情
(II) 12499 5-cyano-6-hydroxy-2-pyridinyl benzoate C13H8N2O3 详情 详情
(III) 12500 1-(Ethoxymethyl)-5-fluoro-2,4(1H,3H)-pyrimidinedione C7H9FN2O3 详情 详情
(IV) 12501 Isophthaloyl dichloride 99-63-8 C8H4Cl2O2 详情 详情
(V) 12502 2,6-Dihydroxynicotinonitrile C6H4N2O2 详情 详情
(VI) 10463 Benzoyl chloride 98-88-4 C7H5ClO 详情 详情
Extended Information