|
【结 构 式】 
|
【分子编号】12481 【品名】(1S,2S,3R,4S,7R,9R,10R,12R,15S)-4-(acetoxy)-15-[[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-(1-ethoxyethoxy)-3-phenylpropanoyl]oxy]-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9,12-bis[2-oxo-2-(trityloxy)ethyl]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate 【CA登记号】 |
【 分 子 式 】C89H93NO17 【 分 子 量 】1448.71396 【元素组成】C 73.79% H 6.47% N 0.97% O 18.77% |
合成路线1
该中间体在本合成路线中的序号：(II)Docetaxel is a synthetic derivative of 10-deacetylbaccatin III (10-DAB; RP 61387). The crystalline active ingredient is synthesized by a sequence of more than 10 chemical steps. The optically active side-chain (RPR 108278) is first fully synthesized and coupled with suitably protected 10-DAB. The resulting intermediate is then deprotected to give docetaxel which is crystallized.
| 【1】 Locci-Tonelli, D.; Spiridonidis, C.H.; Fabre, J.L.; Docetaxel. Drugs Fut 1995, 20, 5, 464. |
| 【2】 Colin, M.; Guenard, D.; Gueritte-Voegelein, F.; Potier, P. (Aventis SA); Process for preparing derivs. of baccatine III and of 10-deacetyl baccatine III. US 4924012 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12479 | (1S,2S,3R,4S,7R,9R,10R,12R,15S)-4-(acetoxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9,12-bis[2-oxo-2-(trityloxy)ethyl]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C71H68O12 | 详情 | 详情 | |
| (II) | 12481 | (1S,2S,3R,4S,7R,9R,10R,12R,15S)-4-(acetoxy)-15-[[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-(1-ethoxyethoxy)-3-phenylpropanoyl]oxy]-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9,12-bis[2-oxo-2-(trityloxy)ethyl]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C89H93NO17 | 详情 | 详情 |