【结 构 式】 |
【分子编号】12476 【品名】3-Nitro-1H-1,2,4-triazole; 3-Nitro-1,2,4-triazole 【CA登记号】24807-55-4 |
【 分 子 式 】C2H2N4O2 【 分 子 量 】114.06364 【元素组成】C 21.06% H 1.77% N 49.12% O 28.05% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Condensation of aminoguanidine carbonate (I) with formic acid gives 3-aminotriazole (II), which by treatment with concentrated nitric acid in a sodium nitrite solution gives 3-nitrotriazole (III). N-Alkylation of (III) with bromoacetic acid ethyl ester affords 2-(3-nitro-1,2,4-triazol-1-yl)acetic acid ethyl ester (IV). Reaction of (IV) with 2-methoxyethylamine in dioxane yields AK-2123.
【1】 Horning, E.C.; Organic Syntheses, Vol. 3, 1st Ed. University of Missouri 1995, 95. |
【2】 Sugita, T.; Masuoka, M.; Nishikawa, Y.; Nishimoto, S.; Zhuo, L.; Sasai, K.; Kagiya, T.; Nitrotriazoles bearing sulfur-substituted side chains: Preparation and characterization as hypoxic cell radiosensitizers. Anti-Cancer Drug Des 1992, 7, 277-84. |
【3】 Huan, L.C.; Rong, S.; AK-2123. Drugs Fut 1995, 20, 7, 659. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
16640 | Ethyl 2-bromoacetate; Ethyl bromoacetate | 105-36-2 | C4H7BrO2 | 详情 | 详情 | |
34675 | 2-methoxyethylamine; 2-methoxy-1-ethanamine | 109-85-3 | C3H9NO | 详情 | 详情 | |
(I) | 10015 | 1-Hydrazinecarboximidamide; Hydrazinecarboximidamide | 79-17-4 | CH6N4 | 详情 | 详情 |
(II) | 12475 | 1H-1,2,4-Triazol-3-amine; 1H-1,2,4-Triazol-3-ylamine | 61-82-5 | C2H4N4 | 详情 | 详情 |
(III) | 12476 | 3-Nitro-1H-1,2,4-triazole; 3-Nitro-1,2,4-triazole | 24807-55-4 | C2H2N4O2 | 详情 | 详情 |
(IV) | 12477 | ethyl 2-(3-nitro-1H-1,2,4-triazol-1-yl)acetate | C6H8N4O4 | 详情 | 详情 |
Extended Information