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【结 构 式】

【分子编号】12464

【品名】11H-Dibenzo[b,e]azepine-6-carbonitrile

【CA登记号】

【 分 子 式 】C15H10N2

【 分 子 量 】218.25788

【元素组成】C 82.55% H 4.62% N 12.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

A new synthesis of epinastine hydrochloride has been described: The reaction of 6-chloro-11H-dibenzo[b,e]azepine (I) with NaCN in DMSO at 90 C gives 11H-dibenzo[b,e]azepine-6-carbonitrile (II), which is reduced with AlH3 (prepared from LiAlH4 and H2SO4 in THF) in THF to afford 6-(aminomethyl)-6,11-dihydro-5H-dibenzo[b,e]azepine (III). Finally, this compound is cyclized with cyanogen bromide in THF and treated with HCl.

1 Walther, G.; Bechtel, W.D.; Daniel, H.; Brandt, K.; New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine. Arzneim-Forsch Drug Res 1990, 40, 4, 440-6.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12463 6-Chloro-11H-dibenzo[b,e]azepine C14H10ClN 详情 详情
(II) 12464 11H-Dibenzo[b,e]azepine-6-carbonitrile C15H10N2 详情 详情
(III) 12465 6,11-Dihydro-5H-dibenzo[b,e]azepin-6-ylmethylamine; 6,11-Dihydro-5H-dibenzo[b,e]azepin-6-ylmethanamine C15H16N2 详情 详情
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