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【结 构 式】 
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【分子编号】12212 【品名】(2R,3R,3aS,9aR)-2-[(acetoxy)methyl]-7-methyl-6-oxo-2,3,3a,5,6,9a-hexahydro-4aH-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-yl acetate 【CA登记号】 |
【 分 子 式 】C14H18N2O7 【 分 子 量 】326.3062 【元素组成】C 51.53% H 5.56% N 8.59% O 34.32% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVII)6) Another route involves acetylation of the anhydro derivative (XVI) to give (XVII), which is converted to (XVIII) by treatment with sodium bromide in sulfuric acid and submitted to elimination with zinc and sodium hydroxide.
| 【1】 Ikeda, T.; Asamura, K. (Yamasa Shoyu Co., Ltd.); Process for producing 1-(2,3-dideoxy-beta-D-glycero-pent-enofuranosyl)thymine. WO 9209599 . |
| 【2】 Robinson, C.; Castaner, J.; Stavudine. Drugs Fut 1994, 19, 10, 925. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVI) | 12211 | (2R,3R,3aS,9aR)-3-Hydroxy-2-(hydroxymethyl)-7-methyl-2,3,3a,4a,5,9a-hexahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-6-one | C10H14N2O5 | 详情 | 详情 | |
| (XVII) | 12212 | (2R,3R,3aS,9aR)-2-[(acetoxy)methyl]-7-methyl-6-oxo-2,3,3a,5,6,9a-hexahydro-4aH-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-yl acetate | C14H18N2O7 | 详情 | 详情 | |
| (XVIII) | 12213 | [(2R,3R,4R,5R)-3-(acetoxy)-4-bromo-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl acetate | C14H17BrN2O7 | 详情 | 详情 |
Extended Information