【结 构 式】 |
【分子编号】12094 【品名】2-(3-Fluorobenzoyl)-N,1-dimethyl-1-hydrazinecarbothioamide 【CA登记号】 |
【 分 子 式 】C10H12FN3OS 【 分 子 量 】241.2893032 【元素组成】C 49.78% H 5.01% F 7.87% N 17.41% O 6.63% S 13.29% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)The reaction of methyl hydrazine (I) and methyl isothiocyanate (II) in either ethanol or THF afforded 2,4-dimethylthiosemicarbazide (III). Acylation of (III) with 3-fluorobenzoyl chloride in either pyridine or THF/N(Et)3 yielded 1-(3-fluorobenzoyl)-2,4-dimethylthiosemicarbazide (IV), which was easily cyclized to MDL 26,479 by warming in 1 M aqueous NaOH.
【1】 Miller, J.A.; Dudley, M.W.; Kehne, J.H.; Sorensen, S.M.; Wenstrup, D.L.; Kane J.M.; MDL 26,479. Drugs Fut 1992, 17, 1, 21. |
【2】 Dudley, M.W.; Baron, B.M.; Sorensen, S.M.; Miller, F.P.; MDL 26,479: A potential antidepressant whose mechanism of action involves interaction at the GABAA receptor complex. 29th Annu Meet Amer Coll Neuropsychopharmacol (Dec 10-14, San Juan) 1990, Abst. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
63420 | 3-fluorobenzoyl chloride | C7H4ClFO | 详情 | 详情 | ||
(I) | 12091 | 1-Methylhydrazine; Monomethyl hydrazine | 60-34-4 | CH6N2 | 详情 | 详情 |
(II) | 12092 | Methyl isothiocyanate; MITC; (Methylimino)(thioxo)methane | 556-61-6 | C2H3NS | 详情 | 详情 |
(III) | 12093 | 2,4-Dimethylthiosemicarbazide; N,1-Dimethyl-1-hydrazinecarbothioamide | 6621-75-6 | C3H9N3S | 详情 | 详情 |
(IV) | 12094 | 2-(3-Fluorobenzoyl)-N,1-dimethyl-1-hydrazinecarbothioamide | C10H12FN3OS | 详情 | 详情 |
Extended Information