• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】11830

【品名】8-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-8-oxooctanoic acid

【CA登记号】

【 分 子 式 】C30H42O8

【 分 子 量 】530.65868

【元素组成】C 67.9% H 7.98% O 24.12%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XI)

3) The title product labeled at 1, 2 and 4 positions is synthesized starting from [1,2,4-3H]-methylprednisolone and using the method described in the preceding paragraph to finally yield [1,2,4-3H]-methylprednisolone suleptanate. 4) The title product [14C]-labeled at the CO groups of the suberic acid is synthesized starting from methylprednisolone 21-O-mesylate (IX), which is condensed with [1,8-14C]-suberic acid (X) by means of diisopropyl ethylamine in DMF to yield the corresponding hemisuberate (XI). Finally, this compound is condensed with N-methyltaurine sodium salt (II) by means of isobutyl chloroformate as before.

1 Stolle, W.T.; Runge, T.A.; Hsi, R.S.P.; Synthesis of carbon-14 and tritium labeled methylprednisolone suleptanate. J Label Compd Radiopharm 1990, 28, 255-80.
2 Graul, A.; Leeson, J.; Castaner, J.; Methylprednisolone Suleptanate. Drugs Fut 1997, 22, 8, 833.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(II) 11821 sodium 2-(methylamino)-1-ethanesulfonate 4316-74-9 C3H8NNaO3S 详情 详情
(IX) 11828 2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl methanesulfonate C23H32O7S 详情 详情
(X) 11820 Suberic acid; Cork acid; Octanedioic acid 505-48-6 C8H14O4 详情 详情
(X) 45087 suberic acid C8H14O4 详情 详情
(XI) 11830 8-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-8-oxooctanoic acid C30H42O8 详情 详情
(XI) 45088 8-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-8-oxooctanoic acid C30H42O8 详情 详情
Extended Information