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【结 构 式】

【分子编号】11768

【品名】Chrysene

【CA登记号】218-01-9

【 分 子 式 】C18H12

【 分 子 量 】228.29328

【元素组成】C 94.7% H 5.3%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The formylation of chrysene (I) with dichloromethyl methyl ether by means of SnCl4 in o-dichlorobenzene gives chrysene-6-carboxaldehyde (II), which is then reductocondensed with 2-amino-2-methylpropane-1,3-diol (III) by means of p-toluenesulfonic acid in refluxing toluene, followed by dilution with ethanol and reduction with sodium cyanoborohydride.

1 Bair, K.W. (Glaxo Wellcome plc); Polycyclic aromatic cpds. EP 0125702; US 4719047 .
2 Bair, K.W. (Glaxo Wellcome plc); Polycyclic biocidal cpds., their synthesis, formulations containing them. EP 0182609; ES 8706102; ES 8802415; ES 8802481 .
3 Andrews, C.W.; Tuttle, R.L.; Cory, M.; McKee, D.D.; Bair, K.W.; Knick, V.C.; 2-[(Arylmethyl)amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding. J Med Chem 1991, 34, 7, 1983-90.
4 Castaner, J.; Prous, J.; Crisnatol Mesylate. Drugs Fut 1993, 18, 3, 216.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11768 Chrysene 218-01-9 C18H12 详情 详情
(II) 11769 6-Chrysenecarbaldehyde C19H12O 详情 详情
(III) 11770 2-Amino-2-methyl-1,3-propanediol 115-69-5 C4H11NO2 详情 详情
Extended Information