(2S)-2-Methoxy-2-(2-oxoethoxy)ethanal -Drug Synthesis Database

【结构式】

【分子编号】11674

【品名】(2S)-2-Methoxy-2-(2-oxoethoxy)ethanal

【CA登记号】

【分子式】C₅H₈O₄

【分子量】132.11612

【元素组成】C 45.46% H 6.1% O 48.44%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The oxidative cleavage of methyl beta-L-arabinopyranoside (I) with sodium periodate in water gives the dialdehyde (II), which is then cyclized with daunorubicin by means of NaHCO3 and sodium cyanoborohydride in acetonitrile/water.

参考文献中间体

合成目标

【1】 Graul, A.; Leeson, P.; Castaner, J.; Nemorubicin. Drugs Fut 1997, 22, 12, 1239.
【2】 Bargiotti, A.; Zini, P.; Penco, S.; Giuliani, F. (Pharmacia Corp.); Novel morpholino derivs. of daunorubicins and doxorubicins. BE 0904431; DE 3609052; GB 2172594; JP 1986221194; US 4672057 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	11673	(2S,3R,4S,5S)-2-Methoxytetrahydro-2H-pyran-3,4,5-triol	C₆H₁₂O₅	详情	详情
(II)	11674	(2S)-2-Methoxy-2-(2-oxoethoxy)ethanal	C₅H₈O₄	详情	详情
(III)	11675	(8S,10S)-10-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-8-glycoloyl-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-naphthacenedione	C₂₇H₂₉NO₁₁	详情	详情

Extended Information