diethyl 2-[2-(2-amino-9H-purin-9-yl)ethyl]malonate -Drug Synthesis Database

【结构式】

【分子编号】11649

【品名】diethyl 2-[2-(2-amino-9H-purin-9-yl)ethyl]malonate

【CA登记号】

【分子式】C₁₄H₁₉N₅O₄

【分子量】321.33616

【元素组成】C 52.33% H 5.96% N 21.79% O 19.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIV)

A synthesis of famciclovir that corresponds to that previously published and studies on its oral bioavailability in rats and mice, identifying famciclovir as the preferred prodrug of BRL-39123 (penciclovir), have been published.

参考文献中间体

合成目标

【1】 Choudary, B.M.; Geen, G.R.; Kincey, P.M.; Parratt, M.J.; Dales, J.R.M.; Johnson, G.P.; O'Donnell, S.; Tudor, D.W.; Woods, N.; A direct approach to the synthesis of famciclovir and penciclovir. Nucleosides Nucleotides 1996, 15, 5, 981.
【2】 Harnden, M.R.; Boyd, M.R.; Vere Hodge, R.A.; Jarvest, R.L.; Sutton, D.; Prodrugs of the selective antiherpesvirus agent 9-[4-hydroxy-3-(hydroxy methyl)but-1-yl]guanine (BRL 39123) with improved gastrointestinal absorption properties. J Med Chem 1989, 32, 1738-43.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11636	6,8-Dichloro-9H-purin-2-ylamine; 6,8-Dichloro-9H-purin-2-amine		C₅H₃Cl₂N₅	详情	详情
(II)	11637	dimethyl 3-(2-iodoethyl)pentanedioate		C₉H₁₅IO₄	详情	详情
(III)	11638	2-[(acetoxy)methyl]-4-(2-amino-6,8-dichloro-9H-purin-9-yl)butyl acetate		C₁₄H₁₇Cl₂N₅O₄	详情	详情
(IV)	11639	6,6-Dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione	5617-70-9	C₈H₁₀O₄	详情	详情
(V)	11640	5-[2-(2-amino-6,8-dichloro-9H-purin-9-yl)ethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione		C₁₃H₁₃Cl₂N₅O₄	详情	详情
(VI)	11641	5-[2-(2-amino-9H-purin-9-yl)ethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione		C₁₃H₁₅N₅O₄	详情	详情
(VII)	11642	dimethyl 2-[2-(2-amino-9H-purin-9-yl)ethyl]malonate		C₁₂H₁₅N₅O₄	详情	详情
(VIII)	11643	2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol		C₁₀H₁₅N₅O₂	详情	详情
(IX)	11644	6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurine	10310-21-1	C₅H₄ClN₅	详情	详情
(X)	11645	5-[2-(2-Amino-6-chloro-9H-purin-9-yl)ethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione		C₁₃H₁₄ClN₅O₄	详情	详情
(XI)	11646	triethyl 3-bromo-1,1,1-propanetricarboxylate		C₁₂H₁₉BrO₆	详情	详情
(XII)	11647	triethyl 3-(2-amino-6-chloro-9H-purin-9-yl)-1,1,1-propanetricarboxylate		C₁₇H₂₂ClN₅O₆	详情	详情
(XIII)	11648	triethyl 3-(2-amino-9H-purin-9-yl)-1,1,1-propanetricarboxylate		C₁₇H₂₃N₅O₆	详情	详情
(XIV)	11649	diethyl 2-[2-(2-amino-9H-purin-9-yl)ethyl]malonate		C₁₄H₁₉N₅O₄	详情	详情

Extended Information