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【结 构 式】

【分子编号】20172

【品名】2-(chloromethyl)-4-methoxy-3-methylpyridine; 2-(chloromethyl)-3-methyl-4-pyridinyl methyl ether

【CA登记号】

【 分 子 式 】C8H10ClNO

【 分 子 量 】171.62624

【元素组成】C 55.99% H 5.87% Cl 20.66% N 8.16% O 9.32%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(I)

The condensation of 2-(chloromethyl)-4-methoxy-3-methylpyridine (I) with 5-(1-pyrrolidinyl)benzimidazole-2-thiol (II) by means of NaOH in hot methanol gives 2-(4-methoxy-3-methyl-2-pyridylmethylsulfanyl)-5-(1-pyrrolidinyl)benzimidazole (III), which is finally oxidized with m-chloroperbenzoic acid (MCPBA) in chloroform.

1 Kim, S.U.; Kim, D.Y.; Chung, G.J.; Hong, S.K.; Park, S.J.; Nam, S.H.; Lee, Y.S. (Il-Yang Pharmaceutical Co., Ltd.); Novel 5-pyrrolyl-2-pyridylmethylsulfinyl benzimidazole derivs.. EP 0696281; JP 1997503000; US 5703097; WO 9523140 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 20172 2-(chloromethyl)-4-methoxy-3-methylpyridine; 2-(chloromethyl)-3-methyl-4-pyridinyl methyl ether C8H10ClNO 详情 详情
(II) 20173 5-(1H-pyrrol-1-yl)-1H-benzimidazol-2-ylhydrosulfide; 5-(1H-pyrrol-1-yl)-1H-benzimidazole-2-thiol C11H9N3S 详情 详情
(III) 20174 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfanyl]-5-(1H-pyrrol-1-yl)-1H-benzimidazole; methyl 3-methyl-2-([[5-(1H-pyrrol-1-yl)-1H-benzimidazol-2-yl]sulfanyl]methyl)-4-pyridinyl ether C19H18N4OS 详情 详情

合成路线2

该中间体在本合成路线中的序号:(VI)

The synthesis of IY-81149 can be obtained according to Scheme 22875502a. The oxidation of 2,3-lutidine (I) with hydrogen peroxide in acetic acid affords 2,3-dimethylpyridine-N-oxide (II), which is treated with sulfuric acid and nitric acid to give the corresponding nitro compound (III). The treatment of (III) with NaOH in methanol gives 2,3-dimethyl-4-methoxypyridine-N-oxide (IV), which is reacted with acetic acid and acetic anhydride and oxidized in refluxing NaOH, yielding 3-methyl-4-methoxypyridine-2-methanol (V). The chlorination of (V) with thionylchloride in CH2Cl2 affords 3-methyl-4-methoxy-2-chloromethylpyridine (VI). The reaction of 2-mercapto-5-nitrobenzimidazole (VII) with iron and concentrated HCl in refluxing ethanol and water gives monoamine (VIII), which by condensation with 2,5-dimethoxytetrahydrofuran (IX) in acetic acid yields 2-mercapto-5-(1-pyrrolyl)benzimidazole (X). The condensation of (VI) with (X) by means of NaOH in methanol gives 2-[(4-methoxy-3-methyl-2-pyridinyl)methylsulfanyl]-5-(1H-pyrrol-1-yl)-1H-benzimidazole (XI), which is finally treated with m-chloroperoxybenzoic acid (m-CPBA) in chloroform.

1 Lee, S.M.; Jung, W.T.; Kim, D.Y.; IY-81149. Drugs Fut 1999, 24, 6, 618.
2 Kohl, B.; Sturm, E.; Senn-Bilfinger, J.; Simon, W.A.; Krüger, U.; Schaefer, H.; Rainer, G.; Figala, V.; Klemm, K.; (H+,K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate. J Med Chem 1992, 35, 6, 1049.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 26309 2,3-Dimethylpyridine 583-61-9 C7H9N 详情 详情
(II) 26310 2,3-dimethyl-1-pyridiniumolate C7H9NO 详情 详情
(III) 19482 2,3-dimethyl-4-nitro-1-pyridiniumolate 37699-43-7 C7H8N2O3 详情 详情
(IV) 26311 4-methoxy-2,3-dimethyl-1-pyridiniumolate C8H11NO2 详情 详情
(V) 26312 (4-methoxy-3-methyl-2-pyridinyl)methanol C8H11NO2 详情 详情
(VI) 20172 2-(chloromethyl)-4-methoxy-3-methylpyridine; 2-(chloromethyl)-3-methyl-4-pyridinyl methyl ether C8H10ClNO 详情 详情
(VII) 26313 5-nitro-1H-benzimidazol-2-ylhydrosulfide; 2-Mercapto-5-nitrobenzimidazole; 5-nitro-1H-benzimidazole-2-thiol 34202-69-2 C7H5N3O2S 详情 详情
(VIII) 26314 5-amino-1H-benzimidazol-2-ylhydrosulfide; 5-amino-1H-benzimidazole-2-thiol C7H7N3S 详情 详情
(IX) 12132 2,5-Dimethoxytetrahydrofuran; 5-Methoxytetrahydro-2-furanyl methyl ether 696-59-3 C6H12O3 详情 详情
(X) 20173 5-(1H-pyrrol-1-yl)-1H-benzimidazol-2-ylhydrosulfide; 5-(1H-pyrrol-1-yl)-1H-benzimidazole-2-thiol C11H9N3S 详情 详情
(XI) 20174 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfanyl]-5-(1H-pyrrol-1-yl)-1H-benzimidazole; methyl 3-methyl-2-([[5-(1H-pyrrol-1-yl)-1H-benzimidazol-2-yl]sulfanyl]methyl)-4-pyridinyl ether C19H18N4OS 详情 详情
Extended Information