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【结 构 式】 
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【分子编号】18285 【品名】methyl (E)-7-[4-(4-[[(4-cyclohexylbutyl)amino]carbonyl]-1,3-oxazol-2-yl)phenyl]-7-(3-pyridinyl)-6-heptenoate 【CA登记号】 |
【 分 子 式 】C33H41N3O4 【 分 子 量 】543.70636 【元素组成】C 72.9% H 7.6% N 7.73% O 11.77% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)Oxazolidine (XIII) was oxidized to oxazole (XIV) with nickel peroxide in the presence of 4 Å molecular sieves, and finally hydrolyzed with 1 M NaOH in THF-MeOH to the title acid.
| 【1】 Takeuchi, K.; Kohn, T.J.; Mais, D.E.; True, T.A.; Wyss, V.L.; Jakubowski, J.A.; Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives. Bioorg Med Chem Lett 1998, 8, 15, 1943-1948. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIII) | 18284 | methyl (E)-7-[4-((4S)-4-[[(4-cyclohexylbutyl)amino]carbonyl]-4,5-dihydro-1,3-oxazol-2-yl)phenyl]-7-(3-pyridinyl)-6-heptenoate | C33H43N3O4 | 详情 | 详情 | |
| (XIV) | 18285 | methyl (E)-7-[4-(4-[[(4-cyclohexylbutyl)amino]carbonyl]-1,3-oxazol-2-yl)phenyl]-7-(3-pyridinyl)-6-heptenoate | C33H41N3O4 | 详情 | 详情 |
Extended Information