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【结 构 式】

【分子编号】16316

【品名】phenyl N-[4-[4-(4-methoxyphenyl)piperazino]phenyl]carbamate

【CA登记号】

【 分 子 式 】C24H25N3O3

【 分 子 量 】403.48092

【元素组成】C 71.44% H 6.25% N 10.41% O 11.9%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VII)

The intermediate (I) can be obtained as follows:1) The condensation of 1-(4-methoxyphenyl)piperazine (III) with chloronitrobenzene (IV) by means of K2CO3 in DMSO gives 1-(4-methoxyphenyl)-4-(4-nitrophenyl)piperazine (V), which is reduced with H2 over Pt/C to the corresponding amine (VI). The reaction of (VI) with phenyl chloroformate and pyridine in CHCl3 affords the corresponding carbamate (VII), which is treated with hydrazine in dioxane/water yielding the semicarbazide (VIII). The cyclization of (VIII) with formamidine and sodium acetate in butanol gives 4-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]-3,4-dihydro-2H-1,2,4-triazol-3-one (IX) (2), which is alkylated with 1-ethylpropyl tosylate (X) by means of KOH in DMSO yielding the corresponding 2-alkyl compound (XI). Finally, this compound is demethylated to (I) by refluxing in 48% HBr.

1 Van Cutsem, J.; Backx, L.J.J.; Heeres, J.; J. Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones. J Med Chem 1984, 27, 7, 894-900.
2 Castañer, J.; Fromtling, R.A.; SCH 51048. Drugs Fut 1995, 20, 3, 241.
3 Saksena, A.K.; Girijavallabhan, V.M.; Ganguly, A.K.; Lovey, R.G. (Schering Corp.); Tri-substd. tetrahydrofuran antifungals. EP 0610377; JP 1995500605; WO 9309114 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 16310 2-(1-ethylpropyl)-4-[4-[4-(4-hydroxyphenyl)piperazino]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one C23H29N5O2 详情 详情
(III) 16312 1-(4-Methoxyphenyl)piperazine; Methyl 4-piperazinophenyl ether 38212-30-5 C11H16N2O 详情 详情
(IV) 13909 1-Chloro-4-nitrobenzene; p-Nitrochlorobenzene 100-00-5 C6H4ClNO2 详情 详情
(V) 16314 methyl 4-[4-(4-nitrophenyl)piperazino]phenyl ether; 1-(4-methoxyphenyl)-4-(4-nitrophenyl)piperazine C17H19N3O3 详情 详情
(VI) 16315 4-[4-(4-methoxyphenyl)piperazino]phenylamine; 4-[4-(4-methoxyphenyl)piperazino]aniline; 1-(4-Aminophenyl)-4-(4-methoxyphenyl)piperazine 74852-62-3 C17H21N3O 详情 详情
(VII) 16316 phenyl N-[4-[4-(4-methoxyphenyl)piperazino]phenyl]carbamate C24H25N3O3 详情 详情
(VIII) 16317 N-[4-[4-(4-methoxyphenyl)piperazino]phenyl]-1-hydrazinecarboxamide C18H23N5O2 详情 详情
(IX) 16318 4-[4-[4-(4-methoxyphenyl)piperazino]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one C19H21N5O2 详情 详情
(X) 16319 1-ethylpropyl 4-methylbenzenesulfonate C12H18O3S 详情 详情
(XI) 16320 2-(1-ethylpropyl)-4-[4-[4-(4-methoxyphenyl)piperazino]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one C24H31N5O2 详情 详情
Extended Information