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【结 构 式】

【分子编号】11431

【品名】4-Chloro-1-(4-fluorophenyl)-1-butanone

【CA登记号】

【 分 子 式 】C10H10ClFO

【 分 子 量 】200.6399032

【元素组成】C 59.86% H 5.02% Cl 17.67% F 9.47% O 7.97%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

A new synthesis of [18F]-labeled BMY-14802 has been described: The fluorination of 4-(cyclopropylcarbonyl)nitrobenzene (I) with [18F]-CsF in DMSO - 5% water at 180 C gives 4-fluorophenylcyclopropylmethanone (II), which is treated with HCl in methanol, yielding 4-chloro-1-(4-fluorophenyl)-1-butanone (III). The condensation of (III) with 5-fluoro-2-piperazinopyrimidine (VI) affords 1-(4-fluorophenyl)-4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]-1-butan one (V), which is finally reduced with NaBH4 in methanol.

1 Shea, C.; Taylor, D.P.; Ding, Y.S.; Wolf, A.P.; Logan, J.; Volkow, N.D.; Gatley, S.J.; Fowler, J.S.; Dewey, S.L.; Synthesis and PET studies of fluorine-18-BMY-14802 - A potential antipsychotic drug. J Nucl Med 1993, 34, 2, 246.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11423 Cyclopropyl(4-nitrophenyl)methanone C10H9NO3 详情 详情
(II) 11424 Cyclopropyl(4-fluorophenyl)methanone C10H9FO 详情 详情
(II) 27427 cyclopropyl(4-fluorophenyl)methanone 772-31-6 C10H9FO 详情 详情
(III) 11431 4-Chloro-1-(4-fluorophenyl)-1-butanone C10H10ClFO 详情 详情
(III) 35864 4-chloro-1-(4-fluorophenyl)-1-butanone 3874-54-2 C10H10ClFO 详情 详情
(IV) 11426 5-Fluoro-2-piperazinopyrimidine C8H11FN4 详情 详情
(V) 11427 1-(4-Fluorophenyl)-4-[4-(5-fluoro-2-pyrimidinyl)piperazino]-1-butanone C18H20F2N4O 详情 详情
(V) 28024 (2S)-2-(chloromethyl)-1-ethylpyrrolidine C7H14ClN 详情 详情
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