【结 构 式】 |
【分子编号】11431 【品名】4-Chloro-1-(4-fluorophenyl)-1-butanone 【CA登记号】 |
【 分 子 式 】C10H10ClFO 【 分 子 量 】200.6399032 【元素组成】C 59.86% H 5.02% Cl 17.67% F 9.47% O 7.97% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)A new synthesis of [18F]-labeled BMY-14802 has been described: The fluorination of 4-(cyclopropylcarbonyl)nitrobenzene (I) with [18F]-CsF in DMSO - 5% water at 180 C gives 4-fluorophenylcyclopropylmethanone (II), which is treated with HCl in methanol, yielding 4-chloro-1-(4-fluorophenyl)-1-butanone (III). The condensation of (III) with 5-fluoro-2-piperazinopyrimidine (VI) affords 1-(4-fluorophenyl)-4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]-1-butan one (V), which is finally reduced with NaBH4 in methanol.
【1】 Shea, C.; Taylor, D.P.; Ding, Y.S.; Wolf, A.P.; Logan, J.; Volkow, N.D.; Gatley, S.J.; Fowler, J.S.; Dewey, S.L.; Synthesis and PET studies of fluorine-18-BMY-14802 - A potential antipsychotic drug. J Nucl Med 1993, 34, 2, 246. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 11423 | Cyclopropyl(4-nitrophenyl)methanone | C10H9NO3 | 详情 | 详情 | |
(II) | 11424 | Cyclopropyl(4-fluorophenyl)methanone | C10H9FO | 详情 | 详情 | |
(II) | 27427 | cyclopropyl(4-fluorophenyl)methanone | 772-31-6 | C10H9FO | 详情 | 详情 |
(III) | 11431 | 4-Chloro-1-(4-fluorophenyl)-1-butanone | C10H10ClFO | 详情 | 详情 | |
(III) | 35864 | 4-chloro-1-(4-fluorophenyl)-1-butanone | 3874-54-2 | C10H10ClFO | 详情 | 详情 |
(IV) | 11426 | 5-Fluoro-2-piperazinopyrimidine | C8H11FN4 | 详情 | 详情 | |
(V) | 11427 | 1-(4-Fluorophenyl)-4-[4-(5-fluoro-2-pyrimidinyl)piperazino]-1-butanone | C18H20F2N4O | 详情 | 详情 | |
(V) | 28024 | (2S)-2-(chloromethyl)-1-ethylpyrrolidine | C7H14ClN | 详情 | 详情 |
Extended Information