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【结 构 式】

【分子编号】11238

【品名】4-nitrophenyl N-(2-chloroethyl)carbamate

【CA登记号】

【 分 子 式 】C9H9ClN2O4

【 分 子 量 】244.63424

【元素组成】C 44.19% H 3.71% Cl 14.49% N 11.45% O 26.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The reaction of 4-nitrophenol (I) with 2-chloroethyl isocyanate (II) in pyridine leads to the activated carbamate (III), which is nitrosated by reacting with nitrosyl chloride in pyridine at -20 C to yield 4-nitrophenyl N-(2-chloroethyl)-N-nitrosocarbamate (IV). The nitrosated molecule (IV) is reacted with 2-(methylthio)ethylamine (V) in THF at ordinary temperature affording the sulfure urea (VI), which is then oxidized to the sulfonyl compound (VII) by hydrogen peroxide in formic acid at 50 C.

1 Godeneche, D.; Imbach, J.-L.; Madelmont, J.-C.; Meyniel, G.; Moreau, M.-F.; Oiry, J.; Parry, D. (CNRS (Centre National de la Recherche Scientifique); INSERM (Institut National de la Sante et de la Recherche Medicale)); Novel nitrosourea cpds. Process of preparation. Compsns. based on these cpds. useful in anticancer chemotherapy. EP 0185020; FR 2562890; JP 1988502269; WO 8504655 .
2 Madelmont, J.-C.; Godeneche, D.; Moreau, M.-F.; Parry, D.; Meyniel, G.; Oiry, J.; Imbach, J.-L. (CNRS (Centre National de la Recherche Scientifique); INSERM (Institut National de la Sante et de la Recherche Medicale)); Nitrosoureas compounds, preparation thereof and utilization thereof in anticancerous. US 5001158 .
3 Meyniel, G.; Duprat, J.; Mathe, G.; Plagne, R.; Godeneche, D.; Parry, D.; Madelmont, J.C.; Chabard, J.L.; New cysteamin(2-chloroethyl)nitrosoureas. Synthesis and preliminary antitumor results. J Med Chem 1985, 28, 9, 1346-50.
4 Madelmont, J.C.; Cystemustine. Drugs Fut 1994, 19, 1, 27.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11236 4-Nitrophenol; p-Nitrophenol 100-02-7 C6H5NO3 详情 详情
(II) 11237 1-Chloro-2-isocyanatoethane; 2-Chloroethyl isocyanate 1943-83-5 C3H4ClNO 详情 详情
(III) 11238 4-nitrophenyl N-(2-chloroethyl)carbamate C9H9ClN2O4 详情 详情
(IV) 11239 4-nitrophenyl 1-(2-chloroethyl)-2-oxo-1-hydrazinecarboxylate C9H8ClN3O5 详情 详情
(V) 11240 2-(Methylsulfanyl)ethylamine; 2-(Methylthio)ethylamine; 2-(Methylsulfanyl)-1-ethanamine 18542-42-2 C3H9NS 详情 详情
(VI) 11241 1-(2-Chloroethyl)-N-[2-(methylsulfanyl)ethyl]-2-oxo-1-hydrazinecarboxamide C6H12ClN3O2S 详情 详情
Extended Information