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【结 构 式】 
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【分子编号】11148 【品名】2,4,5-trichlorophenyl decanoate 【CA登记号】 |
【 分 子 式 】C16H21Cl3O2 【 分 子 量 】351.69964 【元素组成】C 54.64% H 6.02% Cl 30.24% O 9.1% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)A-21978C nucleus (I) (obtained by deacylating A-21978C complex by fermentation with Actinoplanes utahensis NRRL 12052) is protected with di-tert-butyl carbonate (II) and NaOH in water to give the N-(Orn-)-tert-butoxycarbonyl derivative (III), which is treated with 2,4,5-trichlorophenyl decanoate (IV) in hot DMF yielding the protected decanoyl derivative (V). Finally, this compound is deprotected with trifluoroacetic acid / 1,2-ethanedithiol.
| 【1】 Abbott, B.J.; Debono, M.; Fukuda, D.S. (Eli Lilly and Company); Derivs. of A-21978C cyclic peptides. US 4537717 . |
| 【2】 Dionisi, M.S.; Patoia, L.; Castaner, J.; Daptomycin. Drugs Fut 1991, 16, 7, 608. |
Extended Information