|
【结 构 式】 
|
【分子编号】11018 【品名】5-Carbamoylimidazolidin-4-yldiazonium salt 【CA登记号】 |
【 分 子 式 】C4H3N5O 【 分 子 量 】137.10092 【元素组成】C 35.04% H 2.21% N 51.08% O 11.67% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The synthesis of several forms of [13C]- and [15N]-labeled temozolomide has been reported: 1) The diazotation of 3-aminopyrazole-4-carboxamide (I) with [15N]-labeled sodium nitrite and HCl gives the corresponding labeled diazonium salt (II), which is cyclized with methyl isocyanate (II) at room temperature, yielding temozolomide labeled at the N in the 2-position.
| 【1】 Wilman, D.E.V.; Thomson, W.; Wheelhouse, R.T.; Stevens, M.F.G.; Antitumour imidazotetrazines. 31. The synthesis of isotopically labelled temozolomide and a multinuclear (H-1, C-13, N-15) magnetic resonance investigation of temozolomide and mitozolomide. J Chem Soc - Perkins Trans I 1995, 3, 3, 249. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11015 | 5-Amino-1H-imidazole-4-carboxamide | 360-97-4 | C4H6N4O | 详情 | 详情 |
| (II) | 11018 | 5-Carbamoylimidazolidin-4-yldiazonium salt | C4H3N5O | 详情 | 详情 | |
| (II) | 45040 | 5-(aminocarbonyl)-4-imidazolidinediazonium | C4H8N5O | 详情 | 详情 | |
| (III) | 11019 | (Methylimino)(oxo)methane; methyl isocyanate | C2H3NO | 详情 | 详情 |
Extended Information