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【结 构 式】 
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【分子编号】11000 【品名】5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate 【CA登记号】 |
【 分 子 式 】C19H19N3O6 【 分 子 量 】385.37648 【元素组成】C 59.22% H 4.97% N 10.9% O 24.91% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)1) The synthesis of deuterated nilvadipine has been reported: The selective hydrolysis of nilvadipine (I) with lithium iodide and pyridine gives the monolithium salt (II), which is then treated with perdeuterated methanol and 2-bromo-1-methylpyridinium bromide and dimethylaniline in DMF.
| 【1】 Okumura, K.; Satoh, Y.; Shiokawa, Y.; Studies on nilvadipine. IV. Synthesis of deuterated and optically active isopropyl 2-cyano-3-methoxycarbonyl-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridine-5-carboxylate (nilvadipine). Chem Pharm Bull 1994, 42, 4, 950. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10998 | 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate | C19H19N3O6 | 详情 | 详情 | |
| (II) | 10999 | 2-Cyano-5-(isopropoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid lithium salt | C18H16LiN3O6 | 详情 | 详情 | |
| (III) | 11000 | 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate | C19H19N3O6 | 详情 | 详情 |
Extended Information