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【结 构 式】

【分子编号】10471

【品名】(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-[[(2R,3S)-2-(acetoxy)-3-(benzoylamino)-3-phenylpropanoyl]oxy]-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate

【CA登记号】

【 分 子 式 】C49H53NO15

【 分 子 量 】895.95756

【元素组成】C 65.69% H 5.96% N 1.56% O 26.79%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Two new syntheses of taxol have been described: 1) The oxidative cleavage of 10-deacetyltaxol-7-xyloside (I) with sodium periodate in methanol - chloroform gives 10-deacetyltaxol (II), which is then acetylated with acetic anhydride and pyridine. 2) By deacetylation of 2'-acetyltaxol (III) by means of dimethylamine in aqueous methanol.

1 Rao, K.V. (University of Florida); Process for the preparation of taxol and 10-deacetyltaxol. US 5200534 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10469 (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetoxy)-15-[[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy]-1,12-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[[(2R,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]oxy]-6-oxatetracyclo[11.3.1.0(3,10) C50H57NO17 详情 详情
(II) 10470 (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetoxy)-15-[[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy]-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate C45H49NO13 详情 详情
(III) 10471 (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-[[(2R,3S)-2-(acetoxy)-3-(benzoylamino)-3-phenylpropanoyl]oxy]-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate C49H53NO15 详情 详情
Extended Information