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【结 构 式】 
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【分子编号】10471 【品名】(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-[[(2R,3S)-2-(acetoxy)-3-(benzoylamino)-3-phenylpropanoyl]oxy]-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate 【CA登记号】 |
【 分 子 式 】C49H53NO15 【 分 子 量 】895.95756 【元素组成】C 65.69% H 5.96% N 1.56% O 26.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Two new syntheses of taxol have been described: 1) The oxidative cleavage of 10-deacetyltaxol-7-xyloside (I) with sodium periodate in methanol - chloroform gives 10-deacetyltaxol (II), which is then acetylated with acetic anhydride and pyridine. 2) By deacetylation of 2'-acetyltaxol (III) by means of dimethylamine in aqueous methanol.
| 【1】 Rao, K.V. (University of Florida); Process for the preparation of taxol and 10-deacetyltaxol. US 5200534 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10469 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetoxy)-15-[[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy]-1,12-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[[(2R,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]oxy]-6-oxatetracyclo[11.3.1.0(3,10) | C50H57NO17 | 详情 | 详情 | |
| (II) | 10470 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetoxy)-15-[[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy]-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C45H49NO13 | 详情 | 详情 | |
| (III) | 10471 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-[[(2R,3S)-2-(acetoxy)-3-(benzoylamino)-3-phenylpropanoyl]oxy]-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C49H53NO15 | 详情 | 详情 |
Extended Information