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【结 构 式】

【分子编号】19167

【品名】3-(aminomethyl)benzylamine; [3-(aminomethyl)phenyl]methanamine

【CA登记号】1477-55-0

【 分 子 式 】C8H12N2

【 分 子 量 】136.19676

【元素组成】C 70.55% H 8.88% N 20.57%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(I)

The reaction of m-xylenediamine (I) with triethylamine and di-tert-butyldicarbonate (II) gives the corresponding tert-butyl N-[3-(aminomethyl)benzyl] carbamate hydrochloride (III), which is converted into the tert-butyl N-[3-((acetimidoyl)aminomethyl]benzyl) carbamate hydrochloride (VII) by reaction with S-benzylthioacetimidate hydrochloride (VI). This intermediate (VI) could be obtained by reaction of thioacetamide (IV) with benzyl chloride (V). Finally, compound (VII) is deprotected with HCl to afford the corresponding N-[3-(aminomethyl)benzyl] acetamidine hydrochloride.

1 Itabashi, K.; Takido, T.; An efficient synthesis of unsymmetrical sulfides using liquid-liquid phase transfer catalysis. Synthesis 1987, 817.
2 Oplinger, J.A.; Garvey, E.P.; Furfine, E.S.; Shearer, B.G.; Collins, J.L. (Glaxo Wellcome plc); Acetamidine derivs. and their use as inhibitors for the nitric oxide synthase. EP 0799191; JP 1999500711; US 5866612; WO 9619440 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 19167 3-(aminomethyl)benzylamine; [3-(aminomethyl)phenyl]methanamine 1477-55-0 C8H12N2 详情 详情
(II) 13214 Di-tert-butyldicarbonate; Dicarbonic acid bis(1,1-dimethylethyl) ester; dicarbonic acid di-tert-butyl ester pyrocarbonic acid di-tert-butyl ester; bis(1,1-dimethylethyl) dicarbonate di-tert-butyl pyrocarbonate 24424-99-5 C10H18O5 详情 详情
(III) 19169 tert-butyl N-[3-(aminomethyl)benzyl]carbamate; tert-butyl 3-(aminomethyl)benzylcarbamate 108467-99-8 C13H20N2O2 详情 详情
(IV) 19170 ethanethioamide 62-55-5 C2H5NS 详情 详情
(V) 19171 1-(Chloromethyl)benzene; Benzyl chloride 100-44-7 C7H7Cl 详情 详情
(VI) 19172 benzyl ethanimidothioate C9H11NS 详情 详情
(VII) 19173 tert-butyl 3-[(ethanimidoylamino)methyl]benzylcarbamate C15H23N3O2 详情 详情

合成路线2

该中间体在本合成路线中的序号:(I)

The reaction of m-xylene-alpha,alpha'-diamine (I) with N,N'-bis(tert-butoxycarbonyl)pyrazole-1-carboxamidine (II) in THF gives the protected guanidine (III), which is acylated at the free amino group with 2,3-diphenylpropionyl chloride (IV) and triethylamine in dichloromethane affording the amide (V). The condensation of (V) with tetrahydrofuran-2-ylmethylamine (VI) in refluxing THF affords the protected amidinourea (VII), which is finally treated with TFA in dichloromethane.

1 Biftu, T.; et al.; Synthesis and SAR of oxodiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents. 217th ACS Natl Meet (March 21 1999, Anaheim) 1999, Abst MEDI 138.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 19167 3-(aminomethyl)benzylamine; [3-(aminomethyl)phenyl]methanamine 1477-55-0 C8H12N2 详情 详情
(II) 29482 N,N-bis-Boc-1-guanylpyrazole; tert-butyl (E)-[(tert-butoxycarbonyl)amino](1H-pyrazol-1-yl)methylidenecarbamate 152120-54-2 C14H22N4O4 详情 详情
(III) 29483 tert-butyl (Z)-[[3-(aminomethyl)benzyl]amino][(tert-butoxycarbonyl)amino]methylidenecarbamate C19H30N4O4 详情 详情
(IV) 29484 2,3-diphenylpropanoyl chloride C15H13ClO 详情 详情
(V) 29485 tert-butyl (Z)-[(tert-butoxycarbonyl)amino][(3-[[(2,3-diphenylpropanoyl)amino]methyl]benzyl)amino]methylidenecarbamate C34H42N4O5 详情 详情
(VI) 27335 Tetrahydro-2-furanylmethanamine; Tetrahydrofurfurylamine 4795-29-3 C5H11NO 详情 详情
(VII) 29486 tert-butyl (Z)-[(3-[[(2,3-diphenylpropanoyl)amino]methyl]benzyl)amino]([[(tetrahydro-2-furanylmethyl)amino]carbonyl]amino)methylidenecarbamate C35H43N5O5 详情 详情
Extended Information