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【结 构 式】 
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【分子编号】16353 【品名】8-fluoro[1]benzoxepino[4,3-b]pyridin-11(5H)-one 【CA登记号】 |
【 分 子 式 】C13H8FNO2 【 分 子 量 】229.2104632 【元素组成】C 68.12% H 3.52% F 8.29% N 6.11% O 13.96% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)HSR-609 is obtained as shown in Scheme 20067601a:Tricyclic compound (II), derived from (I) by known methods, is converted to piperidine derivative (III) by Grignard reaction and dehydration. The reaction of (III) with ClCO2Et and KOH affords (IV). Michael reaction and hydrolysis of (IV) give HSR-609.
| 【1】 Iwasaki, N.; Yasuda, S.; Kado, N.; Kato, H.; Ito, Y.; Ohashi, T.; Musoh, K.; Nishino, H.; Amphoteric drugs. III. Synthesis and antiallergic activity of 3-[(5,11-dihydro[1]benzoxepino[4,3-b]pyridin-11-ylidene)piperidino] propionic acid derivatives and related compounds. J Med Chem 1995, 38, 3, 496-507. |
| 【2】 Suzuki, T.; Kato, H.; Nagata, O.; Inomata, N.; Ohashi, T.; HSR-609. Drugs Fut 1998, 23, 4, 379. |
| 【3】 Ito, Y.; Kato, H.; Yasuda, S.; Kado, N.; Iwasaki, N.; Nishino, H.; Takeshita, M. (Hokuriku Seiyaku Co., Ltd.); Amphoteric tricyclic compounds as antihistaminic and antiallergic agents. EP 0556813; JP 1994192263; US 5334594 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 20949 | 4-Chloro-1-methylpiperidine; 4-Chloro-N-methylpiperidine; N-methyl-4-chloropiperidine | 55770-77-4 | C6H12ClN | 详情 | 详情 | |
| (I) | 16352 | furo[3,4-b]pyridin-7(5H)-one | C7H5NO2 | 详情 | 详情 | |
| (II) | 16353 | 8-fluoro[1]benzoxepino[4,3-b]pyridin-11(5H)-one | C13H8FNO2 | 详情 | 详情 | |
| (III) | 16354 | 8-fluoro-11-[1-methyltetrahydro-4(1H)-pyridinylidene]-5,11-dihydro[1]benzoxepino[4,3-b]pyridine | C19H19FN2O | 详情 | 详情 | |
| (IV) | 16355 | 8-fluoro-11-tetrahydro-4(1H)-pyridinylidene-5,11-dihydro[1]benzoxepino[4,3-b]pyridine | C18H17FN2O | 详情 | 详情 |
Extended Information