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【结 构 式】

【分子编号】16681

【品名】(2S)-2-sulfanylpropionic acid

【CA登记号】

【 分 子 式 】C3H6O2S

【 分 子 量 】106.14544

【元素组成】C 33.95% H 5.7% O 30.15% S 30.21%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Methylation of methyl (+)-lactate (I) followed by thioacetylation and acidic hydrolysis affords (-)-thiolactic acid (IV). Reaction of 3-pyridinecarboxyaldehyde (V) with methylamine in toluene under the azeotropic condition provides the imine (VI), which when condensed with (IV) affords (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one (VII). Treatment of (VII) with aqueous HCl/isopropanol results in the precipitation of SM-12502.

1 Koike, H.; Natsume, Y.; Tojo, S.; Morooka, S.; SM-12502. Drugs Fut 1995, 20, 2, 153.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11591 methyl (2R)-2-hydroxypropanoate 17392-83-5 C4H8O3 详情 详情
(II) 16679 methyl (2R)-2-[(methylsulfonyl)oxy]propanoate C5H10O5S 详情 详情
(III) 16680 methyl (2S)-2-(acetylsulfanyl)propanoate C6H10O3S 详情 详情
(IV) 16681 (2S)-2-sulfanylpropionic acid C3H6O2S 详情 详情
(V) 12849 Nicotinaldehyde; 3-Pyridinecarboxaldehyde 500-22-1 C6H5NO 详情 详情
(VI) 16683 N-methyl-N-[(Z)-3-pyridinylmethylidene]amine; N-[(Z)-3-pyridinylmethylidene]methanamine C7H8N2 详情 详情
(VII) 16684 (2R,5S)-3,5-dimethyl-2-(3-pyridinyl)-1,3-thiazolan-4-one C10H12N2OS 详情 详情
Extended Information