【结 构 式】 |
【分子编号】16681 【品名】(2S)-2-sulfanylpropionic acid 【CA登记号】 |
【 分 子 式 】C3H6O2S 【 分 子 量 】106.14544 【元素组成】C 33.95% H 5.7% O 30.15% S 30.21% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Methylation of methyl (+)-lactate (I) followed by thioacetylation and acidic hydrolysis affords (-)-thiolactic acid (IV). Reaction of 3-pyridinecarboxyaldehyde (V) with methylamine in toluene under the azeotropic condition provides the imine (VI), which when condensed with (IV) affords (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one (VII). Treatment of (VII) with aqueous HCl/isopropanol results in the precipitation of SM-12502.
【1】 Koike, H.; Natsume, Y.; Tojo, S.; Morooka, S.; SM-12502. Drugs Fut 1995, 20, 2, 153. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 11591 | methyl (2R)-2-hydroxypropanoate | 17392-83-5 | C4H8O3 | 详情 | 详情 |
(II) | 16679 | methyl (2R)-2-[(methylsulfonyl)oxy]propanoate | C5H10O5S | 详情 | 详情 | |
(III) | 16680 | methyl (2S)-2-(acetylsulfanyl)propanoate | C6H10O3S | 详情 | 详情 | |
(IV) | 16681 | (2S)-2-sulfanylpropionic acid | C3H6O2S | 详情 | 详情 | |
(V) | 12849 | Nicotinaldehyde; 3-Pyridinecarboxaldehyde | 500-22-1 | C6H5NO | 详情 | 详情 |
(VI) | 16683 | N-methyl-N-[(Z)-3-pyridinylmethylidene]amine; N-[(Z)-3-pyridinylmethylidene]methanamine | C7H8N2 | 详情 | 详情 | |
(VII) | 16684 | (2R,5S)-3,5-dimethyl-2-(3-pyridinyl)-1,3-thiazolan-4-one | C10H12N2OS | 详情 | 详情 |
Extended Information