【结 构 式】 |
【分子编号】15282 【品名】3,4-dihydroxy-5-nitrobenzaldehyde 【CA登记号】116313-85-0 |
【 分 子 式 】C7H5NO5 【 分 子 量 】183.12044 【元素组成】C 45.91% H 2.75% N 7.65% O 43.69% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号:(I)Title compound is obtained by reaction of 3,4-dihydroxy-5-nitrobenzaldehyde (I) with N,N-diethyl-2-cyanoacetamide (II) in the presence of piperidine acetate in ethanol.
【1】 Backstrom, R.J.; Heinola, K.E.; Honkanen, E.J.; Kaakkola, S.K.; Karrisalo, P.J.; Linden, I.-B.Y.; Mannisto, P.T.; Nissinen, E.A.O.; Pohto, P.; Pippuri, A.K.; Pystynen, J.J. (Orion Corporation); Novel pharmacologically active cpds., their process of preparation and compsns. containing them. AU 8781879; BE 1003279; CH 685436; DE 3740383; FR 2607493; GB 2200109; JP 1988170311; US 4963590; US 5112861 . |
【2】 Castaner, J.; Prous, J.; Rabasseda, X.; Entacapone. Drugs Fut 1994, 19, 7, 641. |
合成路线2
该中间体在本合成路线中的序号:(II)
【1】 Backstrom RJ, Heinola KE, et aL 1990. Pharmacologunlly active compmmds. metbods for the preparation thereof and compositions containing the same. US 4963590 |
【2】 Pippuri AK, Honkanen EJ, et aL 1992. Stable polymorphic form of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamide and the process for its prepantion. US 5135950 |
Extended Information