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【结 构 式】

【分子编号】12423

【品名】3-Chloro-2-butanone

【CA登记号】4091-39-8

【 分 子 式 】C4H7ClO

【 分 子 量 】106.55168

【元素组成】C 45.09% H 6.62% Cl 33.27% O 15.02%

与该中间体有关的原料药合成路线共 3 条

合成路线1

该中间体在本合成路线中的序号:(IX)

A new synthesis for [14C]-labeled batanopride has been described: The starting material is 4-amino-2-hydroxybenzoic acid labeled with [14C] at the carboxy group (I). The methylation of (I) in the usual way gives 4-amino-2-methoxybenzoic acid methyl ester (II), which is treated with acetic anhydride to yield the corresponding acetamido derivative (III). Chlorination of (III) with Cl2 in acetic acid affords 4-acetamido-5-chloro-2-methoxybenzoic acid methyl ester (IV), which is hydrolyzed with aqueous NaOH to 4-amino-5-chloro-2-methoxybenzoic acid (V). The condensation of (V) with 2-(diethylamino)ethylamine (VI) by means of triethylamine and isobutyl chloroformate in THF gives the corresponding amide (VII), which is demethylated with sodium ethanethiolate in DMF to yield the phenolate (VIII). The condensation of (VIII) with 3-chloro-2-butanone (IX) in DMF affords batanopride free base (X), which is finally treated with HCl in acetone - water.

1 Standridge, R.T.; Swigor, J.E.; Synthesis of 4-amino-5-chloro-N[2-(diethylamino)ethyl]-2-[(butan-2-on-3-yl)oxy]-[carbonyl-C-14]benzamide hydrochloride (C-14-batanopride). J Label Compd Radiopharm 1991, 29, 9, 983.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12415 4-Aminosalicylic Acid; 4-Amino-2-hydroxybenzoic acid 65-49-6 C7H7NO3 详情 详情
(I) 45126 4-amino-2-hydroxybenzoic acid C7H7NO3 详情 详情
(II) 12416 methyl 4-amino-2-methoxybenzoate 27492-84-8 C9H11NO3 详情 详情
(II) 45127 methyl 4-amino-2-methoxybenzoate C9H11NO3 详情 详情
(III) 12417 methyl 4-(acetamido)-2-methoxybenzoate; Methyl 4-acetamido-2-methoxybenzoate 4093-28-1 C11H13NO4 详情 详情
(III) 45128 methyl 4-(acetamido)-2-methoxybenzoate C11H13NO4 详情 详情
(IV) 12418 4-Acetamido-5-chloro-2-methoxy methyl benzoate; methyl 4-(acetamido)-5-chloro-2-methoxybenzoate; Methyl 4-acetamido-5-chloro-2-methoxybenzoate; 4-Acetamido-5-chloro-2-methoxybenzoic acid methyl ester; 4-Acetamido-5-chloro-o-anisic acid methyl ester 4093-31-6 C11H12ClNO4 详情 详情
(IV) 45129 methyl 4-(acetamido)-5-chloro-2-methoxybenzoate C11H12ClNO4 详情 详情
(V) 12419 4-Amino-5-chloro-2-methoxybenzoic acid 7206-70-4 C8H8ClNO3 详情 详情
(V) 45130 4-amino-5-chloro-2-methoxybenzoic acid C8H8ClNO3 详情 详情
(VI) 12420 N-(2-Aminoethyl)-N,N-diethylamine; N,N-Diethylethylene-diamine; N(1),N(1)-Diethyl-1,2-ethanediamine 100-36-7 C6H16N2 详情 详情
(VII) 12421 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide 364-62-5 C14H22ClN3O2 详情 详情
(VII) 45131 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide C14H22ClN3O2 详情 详情
(VIII) 12422 sodium 5-amino-4-chloro-2-([[2-(diethylamino)ethyl]amino]carbonyl)benzenolate C13H19ClN3NaO2 详情 详情
(VIII) 45132 sodium 5-amino-4-chloro-2-([[2-(diethylamino)ethyl]amino]carbonyl)benzenolate C13H19ClN3NaO2 详情 详情
(IX) 12423 3-Chloro-2-butanone 4091-39-8 C4H7ClO 详情 详情
(X) 12424 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(1-methyl-2-oxopropoxy)benzamide C17H26ClN3O3 详情 详情
(X) 45133 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(1-methyl-2-oxopropoxy)benzamide C17H26ClN3O3 详情 详情

合成路线2

该中间体在本合成路线中的序号:(III)

The demethylation of 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide (I) with EtS-Na in hot DMF gives the hydroxy compound (II), which is acylated with 3-chloro-2-butanone (III) by means of K2CO3 and NaI in DMF to yield 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(1-methyl-2-oxopropoxy)benzamide (IV). Finally, this compound is treated with HCl to furnish the target hydrochloride. Alternatively, the alkylation of the hydroxy compound (II) can also be performed by reaction of (II) with tetrabutylammonium bisulfate and NaOH to give the tetrabutylammonium phenolate (V), which is alkylated with the chlorobutanone (III) to give (IV).

1 Monkovic, I.; NEW BENZAMIDE ANTI-EMETICS. Drugs Fut 1989, 14, 1, 41.
2 Monkovic, I.; Willner, D.; Adam, M.A.; Brown, M.; Crenshaw, R.R.; Fuller, C.E.; Juby, P.F.; Luke, G.M.; Matiskella, J.A.; Montzka, T.A.; Substituted benzamides. 1. Potential nondopaminergic antagonists of chemotherapy-induced nausea and emesis. J Med Chem 1988, 31, 8, 1548-58.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12421 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide 364-62-5 C14H22ClN3O2 详情 详情
(II) 43739 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-hydroxybenzamide C13H20ClN3O2 详情 详情
(III) 12423 3-Chloro-2-butanone 4091-39-8 C4H7ClO 详情 详情
(IV) 12424 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(1-methyl-2-oxopropoxy)benzamide C17H26ClN3O3 详情 详情
(V) 43740 N,N,N-tributyl-1-butanaminium 5-amino-4-chloro-2-([[2-(diethylamino)ethyl]amino]carbonyl)benzenolate C29H55ClN4O2 详情 详情

合成路线3

该中间体在本合成路线中的序号:(II)

Condensation of 7-hydroxy-4,8-dimethylcoumarin (I) with 3-chloro-2-butanone (II) affords the keto alkoxycoumarin (III), which is cyclized to the psoralen derivative (IV) under basic conditions. Benzylic bromination of (IV) by means of N-bromosuccinimide provides the bromomethyl compound (V) as the major isomer. Bromide (V) is then condensed with N-(2-hydroxyethyl)phthalimide (VI) to furnish ether (VII). The phthaloyl group of (VII) is removed by treatment with either primary amines or with hydrazine to produce the target free amine, which is finally isolated as the corresponding hydrochloride salt.

1 Wollowitz, S.; Isaacs, S.T.; Rapoport, H.; Spielmann, H.P. (Steritech, Inc.); Cpds. for the photodecontamination of pathogens in blood. US 5399719; WO 9500141 .
2 Wollowitz, S.; Isaacs, S.T.; Rapoport, H.; Spielman, H.P.; Niero, A. (Steritech, Inc.); Cpds. for the photodecontamination of pathogens in blood. WO 9614739 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 58850 4,8-Dimethyl-7-hydroxycoumarin C11H10O3 详情 详情
(II) 12423 3-Chloro-2-butanone 4091-39-8 C4H7ClO 详情 详情
(III) 58851 4,8-dimethyl-7-(1-methyl-2-oxopropoxy)-2H-chromen-2-one C15H16O4 详情 详情
(IV) 58852 2,3,5,9-tetramethyl-7H-furo[3,2-g]chromen-7-one C15H14O3 详情 详情
(V) 58853 3-(bromomethyl)-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one C15H13BrO3 详情 详情
(VI) 58854 2-(2-hydroxyethyl)-1H-isoindole-1,3(2H)-dione;N-Hydroxyethylphthalimide;N-(2-Hydroxyethyl)phthalimide;2-(2-hydroxyethyl)isoindoline-1,3-dione 3891-07-4 C10H9NO3 详情 详情
(VII) 58855 2-{2-[(2,5,9-trimethyl-7-oxo-7H-furo[3,2-g]chromen-3-yl)methoxy]ethyl}-1H-isoindole-1,3(2H)-dione C25H21NO6 详情 详情
Extended Information