(1R,5S)-8-azabicyclo[3.2.1]oct-3-yl 3,5-dichlorobenzoate -Drug Synthesis Database

【结构式】

【分子编号】10371

【品名】(1R,5S)-8-azabicyclo[3.2.1]oct-3-yl 3,5-dichlorobenzoate

【CA登记号】

【分子式】C₁₄H₁₅Cl₂NO₂

【分子量】300.18404

【元素组成】C 56.02% H 5.04% Cl 23.62% N 4.67% O 10.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The synthesis of [11C]-labeled MDL-72222 for use in PET studies of the 5-HT3 receptor by methylation of 3,5-dichlorobenzoic acid 8-azabicyclo[3.2.1]oct-3-yl ester (I) with [11C]-labeled methyl iodide in hot acetonitrile has been described.

参考文献中间体

合成目标

【1】 Lasne, M.C.; Debruyne, D.; Moulin, M.; Baron, J.C.; Camsonne, R.; Barre, L.; Bonvento, G.; Gourand, F.; Synthesis and regional rat brain distribution of [C-11]MDL 72222 - A 5HT3 receptor antagonist. Appl Radiat Isot - Int J Radiat Appl Instrum Part A 1992, 43, 4, 509.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10371	(1R,5S)-8-azabicyclo[3.2.1]oct-3-yl 3,5-dichlorobenzoate		C₁₄H₁₅Cl₂NO₂	详情	详情

Extended Information