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【结 构 式】 
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【分子编号】10346 【品名】methyl (3aR,4R,5S,5aR,10bR,13aR)-4-(acetoxy)-3a-ethyl-9-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0(4,12).0(5,10)]nonadeca-4(12),5,7,9-tetraen-13-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate 【CA登记号】446-86-6 |
【 分 子 式 】C46H58N4O9 【 分 子 量 】810.98808 【元素组成】C 68.13% H 7.21% N 6.91% O 17.76% |
合成路线1
该中间体在本合成路线中的序号：(I)The reaction of vinblastine (I) with 2-chloroethyl isocyanate (II) in refluxing benzene gives the corresponding N-(2-chloroethyl)carbamate (III), which is cyclized by continuous refluxing in the same solvent.
| 【1】 Miller, J.C.; Gutowski, G.E.; Oxazolidinedione derivatives of Vinca alkaloids. FR 2372839; GB 1590649; JP 53071100; US 4096148 . |
| 【2】 Hopkins, S.J.; Vinzolidine Sulfate. Drugs Fut 1984, 9, 12, 913. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10346 | methyl (3aR,4R,5S,5aR,10bR,13aR)-4-(acetoxy)-3a-ethyl-9-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0(4,12).0(5,10)]nonadeca-4(12),5,7,9-tetraen-13-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate | 446-86-6 | C46H58N4O9 | 详情 | 详情 |
| (II) | 11237 | 1-Chloro-2-isocyanatoethane; 2-Chloroethyl isocyanate | 1943-83-5 | C3H4ClNO | 详情 | 详情 |
| (III) | 34248 | C49H62ClN5O10 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)This compound can be obtained by two related ways: 1) The reaction of vinblastine (I) with anhydrous hydrazine in hot ethanol gives 4-deacetylvinblastine-23-acid hydrazide (II), which by reaction with HCl and NaNO2 in cool methanol - water is converted into the corresponding azide (III). Finally, this compound is condensed with L-tryptophan ethyl ester (IV) in dichloromethane. 2) The hydrolysis of vinblastine (I) with NaOH in refluxing ethanol gives 4-deacetylvinblastoic acid (V), which is condensed with L-tryptophan ethyl ester (IV) by means of isobutyl chloroformate (VI) and N-ethylmorpholine in DMF to afford the 4-O-(isobutoxycarbonyl) derivative (VII). Finally, this compound is partially hydrolyzed with KOH in ethanol.
| 【1】 Trouet, A.B.L.; Hannart, J.A.A.J.; Rao, K.S.B. (OmniChem); Vinblastin-23-oyl amino acid derivs. US 4639456 . |
| 【2】 Hamashima, Y. (Shionogi & Co. Ltd.); 7-Carboxyalkenoylamido-3-cephem-4-carboxylic acid derivs.. EP 0136721; ES 8604602; ES 8605278; ES 8700222; GB 2154580; GB 2198727; JP 1985078987; JP 1985163884; JP 1985246388; US 4634697; US 4748170 . |
| 【3】 Trouet, A.B.L.; Rao, K.S.B.; Hannart, J.A.A. (OmniChem); N-Vinblastinoyl-23) derivs. of amino acids and peptides, their preparation and their therapeutic application. EP 0041935 . |
| 【4】 Atassi, G.; Rao, K.S.P.B.; Collard, M.-P.M.; Trouet, A.; Dejonghe, J.P.C.; Hannart, J.A.; Vinblastin-23-oyl amino acid derivatives: Chemistry, physicochemical data, toxicity, and antitumor activities against P388 and L1210 leukemias. J Med Chem 1985, 28, 8, 1079. |
| 【5】 Castaner, J.; Prous, J.; Vintriptol Mesylate. Drugs Fut 1992, 17, 7, 569. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10346 | methyl (3aR,4R,5S,5aR,10bR,13aR)-4-(acetoxy)-3a-ethyl-9-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0(4,12).0(5,10)]nonadeca-4(12),5,7,9-tetraen-13-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate | 446-86-6 | C46H58N4O9 | 详情 | 详情 |
| (II) | 10347 | methyl (13S,15S,17S)-13-[(3aR,4R,5S,5aR,10bR,13aR)-3a-ethyl-5-(hydrazinocarbonyl)-4,5-dihydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazol-9-yl]-17-ethyl-17-hydroxy-1,11-diazatetracyclo[13.3.1.0(4,12).0(5,10)]nonadeca-4(12),5,7,9-tetraene-13-carboxylate | C43H56N6O7 | 详情 | 详情 | |
| (III) | 10348 | 1-([(3aR,4R,5S,5aR,10bR,13aR)-3a-Ethyl-9-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0(4,12).0(5,10)]nonadeca-4(12),5,7,9-tetraen-13-yl]-4,5-dihydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazol-5-yl]carbonyl)-1,2-triazadien-2-ium | C43H53N7O7 | 详情 | 详情 | |
| (IV) | 10349 | ethyl (2S)-2-amino-3-(1H-indol-3-yl)propanoate | C13H16N2O2 | 详情 | 详情 | |
| (V) | 10350 | (3aR,4R,5S,5aR,10bR,13aR)-3a-Ethyl-9-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0(4,12).0(5,10)]nonadeca-4(12),5,7,9-tetraen-13-yl]-4,5-dihydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylic acid | C43H54N4O8 | 详情 | 详情 | |
| (VI) | 13423 | 1-[(Chlorocarbonyl)oxy]-2-methylpropane; Isobutyl chloroformate;isobutyl carbonochloridate | 543-27-1 | C5H9ClO2 | 详情 | 详情 |
| (VII) | 10351 | methyl (13S,15S,17S)-13-[(3aR,4R,5S,5aR,10bR,13aR)-5-([[(1S)-2-ethoxy-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino]carbonyl)-3a-ethyl-5-hydroxy-4-[(isobutoxycarbonyl)oxy]-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazol-9-yl]-17-ethyl-17-hydroxy-1,11-diazatetracyclo[13.3.1.0(4,12).0(5,10)]nonadeca-4(12),5,7,9-tetraene-13-carboxylate | C61H76N6O11 | 详情 | 详情 |