【结 构 式】 |
【分子编号】10245 【品名】2-(Benzylselanyl)-N-phenylbenzamide 【CA登记号】 |
【 分 子 式 】C20H17NOSe 【 分 子 量 】366.32112 【元素组成】C 65.58% H 4.68% N 3.82% O 4.37% Se 21.55% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)A new synthesis of ebselen has been published: The radical reaction of 2-(benzylseleno)-N-phenylbenzamide (I) with triphenyltin hydride (II) and AIBN in refluxing benzene gives N-phenyl-2-(triphenylstannylseleno)benzamide (III), which is treated with dibenzoyl peroxide (IV) in refluxing benzene to yield the diselenide (V). Finally, the diselenide (V) was treated with di-tert-butyl peroxide (VI) in chlorobenzene at 120 C. This reaction cannot be carried out in refluxing benzene due to the extreme insolubility of (V) in benzene.
【1】 Fong, M.C.; Schiesser, C.H.; Reactions of 2,2'-diselenobis(N-alkylbenzamides) with peroxides: A free-radical synthesis of ebselen and related analogues. Tetrahedron Lett 1995, 36, 40, 7329. |
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