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【结 构 式】

【分子编号】10052

【品名】(6aR,9R,10aR)-9-(Hydroxymethyl)-7-methyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-7-ium

【CA登记号】

【 分 子 式 】C19H27N2O

【 分 子 量 】299.43626

【元素组成】C 76.21% H 9.09% N 9.36% O 5.34%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

A new synthesis of pergolide has been reported: The alkylation of 8,9-dihydroelymoclavine (I) with propyl iodide and Na2CO3 in N-methylpyrrolidone gives the quaternary compound (II), which is mesylated with MeSO2Cl in pyridine yielding the mesyl ester (III). Finally, (III) is treated with sodium methylmercaptide in N-methylpyrrolidone.

1 Misner, J.W. (Eli Lilly and Company); One-pot process for preparing pergolide. EP 0571202 .
2 Misner, J.W.; et al.; Integration of a highly selective demethylation of a qaternized ergoline into a one-pot synthesis of pergolide. Org Process Res Dev 1997, 1, 1, 77.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10051 [(6aR,9R,10aR)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl]methanol; 9,10-Dyhydrosergol 18051-16-6 C16H20N2O 详情 详情
(II) 10052 (6aR,9R,10aR)-9-(Hydroxymethyl)-7-methyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-7-ium C19H27N2O 详情 详情
(III) 10053 (6aR,9R,10aR)-7-Methyl-9-[[(methylsulfonyl)oxy]methyl]-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-7-ium C20H29N2O3S 详情 详情
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