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【结 构 式】 
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【分子编号】10003 【品名】2-([2-[(2-Furylmethyl)sulfanyl]ethyl]amino)-5-[(6-methyl-3-pyridinyl)methyl]-4(3H)-pyrimidinone 【CA登记号】72717-05-6 |
【 分 子 式 】C18H20N4O2S 【 分 子 量 】356.44856 【元素组成】C 60.65% H 5.66% N 15.72% O 8.98% S 9% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)A new synthesis of lupitidine has been described: The condensation of 5-(2-methylpyridin-5-yl)-2-(nitroamino)pyrimidin-4(3H)-one (I) with 2-(2-furylmethylthio)ethylamine (II) in refluxing pyridine gives 2-[2-(2-furylmethylthio)ethylamino]-5-(2-methylpyridin-5-ylmethyl)pyrimidin-4(3H)-one (III), which is then submitted to a conventional Mannich condensation with formaldehyde and dimethylamine in acetic acid.
| 【1】 Parsons, M.E.; Rawlings, D.A.; Ife, R.J.; Brown, T.H.; Blakemore, R.C.; Blurton, P.; Armitage, M.A.; Durant, G.J.; Slingsby, B.P.; Ganellin, C.R.; Isocytosine H2-receptor histamine antagonists. III. The synthesis and biological activity of lupitidine (SK&F 93479) and related compounds. Eur J Med Chem 1990, 25, 217-26. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10001 | 5-(2-Methylpyridin-5-yl)-2-(nitroamino)pyrimidin-4(3H)-one | 72716-93-9 | C11H11N5O3 | 详情 | 详情 |
| (II) | 10002 | 2-[(2-Furylmethyl)sulfanyl]-1-ethanamine; 2-[(2-Furylmethyl)sulfanyl]ethylamine; 2-(2-Aminoethyl) furfuryl thiol ether | 36415-21-1 | C7H11NOS | 详情 | 详情 |
| (III) | 10003 | 2-([2-[(2-Furylmethyl)sulfanyl]ethyl]amino)-5-[(6-methyl-3-pyridinyl)methyl]-4(3H)-pyrimidinone | 72717-05-6 | C18H20N4O2S | 详情 | 详情 |
Extended Information