ABD-0056, ABD-56, -Drug Synthesis Database

【结构式】

【药物名称】ABD-0056, ABD-56

【化学名称】Biphenyl-4-carboxylic acid 4-hydroxybutyl ester

【CA登记号】

【分子式】C₁₇H₁₈O₃

【分子量】270.33121

【开发单位】University of Aberdeen (Originator)

【药理作用】Antiarthritic Drugs, Bone Diseases, Treatment of, Bone Resorption Inhibitors, METABOLIC DRUGS, Rheumatoid Arthritis, Treatment of, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Treatment of Osteoporosis, Treatment of Paget's Disease

合成路线1

Biphenyl-4-carbonyl chloride (I) is esterified with 1,4-butanediol (II) in the presence of pyridine to produce the target 4-hydroxybutyl ester.

参考文献中间体

【1】 Greig, I.R.; Ralston, S.H.; Van't Hof, R.J.; Armour, K.J. (University of Aberdeen); Alkane diol derivs. as therapeutic agents for the treatment of bone conditions. WO 0337321 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28439	[1,1'-biphenyl]-4-carbonyl chloride	14002-51-8	C₁₃H₉ClO	详情	详情
(II)	43160	1,4-butanediol;1,4-Dihydroxybutane;1,4-Butylene glycol;Tetramethylene glycol	110-63-4	C₄H₁₀O₂	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)