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【结 构 式】 
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【药物名称】 【化学名称】2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)pyridin-4-amine 【CA登记号】524718-15-8, 524717-65-5 (monohydrochloride) 【 分 子 式 】C14H15N3 【 分 子 量 】225.29575 |
【开发单位】Roche (Originator) 【药理作用】Antiepileptic Drugs, Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, NR1/2B Antagonists |
合成路线1
The title compound is prepared by condensation of 4-amino-2-bromopyridine (I) with an excess of tetrahydroisoquinoline (II) at 130 C
| 【1】 Büttelman, B.; Alanine, A.; Bourson, A.; Gill, R.; Heitz, M.-P.; Mutel, V.; Pinard, E.; Trube, G.; Wyler, R.; 2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists. Bioorg Med Chem Lett 2003, 13, 5, 829. |
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