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【结 构 式】 
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【药物名称】 【化学名称】2-Acetoxybenzoic acid 4-cyano-5-oxido-1,2,5-oxadiazol-3-ylmethyl ester 【CA登记号】 【 分 子 式 】C13H9N3O6 【 分 子 量 】303.23318 |
【开发单位】Università degli Studi di Parma (Originator), Università degli Studi di Torino (Originator), University of Edinburgh (Originator) 【药理作用】Antiarthritic Drugs, Antiplatelet Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Nitric Oxide Donors, Non-Steroidal Antiinflammatory Drugs |
合成路线1
Reaction of acetylsalicylic acid (I) with 4-bromomethyl-3-carbamoylfuroxan (II) provides the furoxanylmethyl ester (III). Subsequent trifluoroacetic anhydride-promoted dehydration of amide (III) yields the corresponding cyano derivative.
| 【1】 Cena, C.; Lolli, M.L.; Lazzarato, L.; Guaita, E.; Morini, G.; Coruzzi, G.; McElroy, S.P.; Megson, I.L.; Fruttero, R.; Gasco, A.; Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin. J Med Chem 2003, 46, 5, 747. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16899 | 2-(Acetoxy)benzoic acid; Aspirin; Acetylsalicylic acid | 50-78-2 | C9H8O4 | 详情 | 详情 |
| (II) | 64270 | 3-(aminocarbonyl)-4-(bromomethyl)-1,2,5-oxadiazol-2-ium-2-olate | C4H4BrN3O3 | 详情 | 详情 | |
| (III) | 64271 | 4-({[2-(acetyloxy)benzoyl]oxy}methyl)-3-(aminocarbonyl)-1,2,5-oxadiazol-2-ium-2-olate | C13H11N3O7 | 详情 | 详情 |
Extended Information