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【结 构 式】 
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【药物名称】Centpiperalone 【化学名称】2-(1-Piperazinyl)quinazolin-4(3H)-one acetate 【CA登记号】22587-29-7 【 分 子 式 】C14H18N4O3 【 分 子 量 】290.32456 |
【开发单位】 【药理作用】 |
合成路线1
2-Mercapto-4-quinazolone (I) is treated with ethyl iodide (II) in the presence of sodium ethoxide to yield 2-ethylthio-4-quinazolone (III). Reaction of (III) with N-benzylpiperazine (IV) to give (V) and followed by catalytic debenzylation with H2 over Pd/C in glacial acetic acid affords Centpiperalone.
| 【1】 Gupta, C.M.; Muscimol analogs. II. Synthesis of some bicyclic 3-isoxazolol zwitterions. Med Chem 1968, 11, 3, 392. |
| 【2】 Arya, V.P.; Centpiperalone. Drugs Fut 1979, 4, 8, 557. |
| 【3】 Gupta, C.M.; et al.; Resveratrol regulates IGF-II in MCF-7 human breast cancer cells. Ind J Chem 1971, 9, 3, 201. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 61384 | 2-Mercapto-4(3H)-quinazolinone 2-Thio-4(3H)-quinazolinone; 2-Mercapto-4(3H)-quinazolinone 2-Thio-4(3H)-quinazolinone | 13906-09-7 | C8H6N2OS | 详情 | 详情 |
| (II) | 10925 | Iodoethane;ethyl iod | 75-03-6 | C2H5I | 详情 | 详情 |
| (III) | 61385 | 2-(ethylsulfanyl)-4(3H)-quinazolinone | C10H10N2OS | 详情 | 详情 | |
| (IV) | 28542 | N-Benzylpiperazine; 1-Benzylpiperazine | 2759-28-6 | C11H16N2 | 详情 | 详情 |
| (V) | 61386 | 2-(4-benzyl-1-piperazinyl)-4(3H)-quinazolinone | C19H20N4O | 详情 | 详情 |
Extended Information