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【结 构 式】 
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【药物名称】 【化学名称】3-(Methylsulfanyl)-4-(2-propynylselanyl)quinoline 【CA登记号】381246-67-9 【 分 子 式 】C13H11NSSe 【 分 子 量 】292.26332 |
【开发单位】Medical University of Silesia (Originator), Polish Academy of Science (Originator) 【药理作用】Oncolytic Drugs |
合成路线1
Condensation of 4-chloro-3-(methylsulfanyl)quinoline (I) with selenourea (II) affords the quinolinyl iso-selenourea (III). Basic hydrolysis of (III), followed by alkylation of the intermediate selenide (IV) with propargyl bromide (V) provides the target propargyl selenoquinoline.
| 【1】 Boryczka, S.; et al.; Synthesis and antiproliferative activity in vitro of new propargyl thioquinolines. Pharmazie 2002, 57, 3, 151. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 57719 | 4-chloro-3-(methylsulfanyl)quinoline; 4-chloro-3-quinolinyl methyl sulfide | C10H8ClNS | 详情 | 详情 | |
| (II) | 57720 | Selenourea | 630-10-4 | CH4N2Se | 详情 | 详情 |
| (III) | 57721 | 4-{[amino(imino)methyl]selanyl}-3-(methylsulfanyl)quinoline | C11H11N3SSe | 详情 | 详情 | |
| (IV) | 57722 | sodium 3-(methylsulfanyl)-4-quinolineselenolate | C10H8NNaSSe | 详情 | 详情 | |
| (V) | 11176 | 3-Bromopropyne; 3-Bromo-1-propyne | 106-96-7 | C3H3Br | 详情 | 详情 |
Extended Information