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【结 构 式】 
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【药物名称】PQ 【化学名称】Acetic acid 2,6-dimethoxy-4-(9-oxo-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ylidenemethyl)phenyl ester 【CA登记号】371766-68-6 【 分 子 式 】C22H20N2O5 【 分 子 量 】392.4151 |
【开发单位】Universidad de Murcia (Originator), Universidad de Valencia (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Antiarthritic Drugs, Non-Opioid Analgesics, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, 5-Lipoxygenase Inhibitors, Cyclooxygenase-2 Inhibitors |
合成路线1
Deoxyvascinone (III) is prepared from o-azidobenzoyl chloride (I) and 2-pyrrolidinone (II) following a reported procedure. Then, Claisen-Schmidt condensation between deoxyvascinone (III) and 4-acetoxy-3,5-dimethoxybenzaldehyde (IV) in boiling acetic anhydride leads to the title compound.
| 【1】 Molina, P.; et al.; Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives. J Nat Prod 2001, 64, 10, 1297. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 56969 | 2-azidobenzoyl chloride | C7H4ClN3O | 详情 | 详情 | |
| (II) | 27397 | 2-Pyrrolidinone | 616-45-5 | C4H7NO | 详情 | 详情 |
| (III) | 56970 | 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one | C11H10N2O | 详情 | 详情 | |
| (IV) | 56971 | O-Acetylsyringaldehyde; 4-Acetoxy-3,5-dimethoxybenzaldehyde | 53669-33-3 | C11H12O5 | 详情 | 详情 |