【结 构 式】 |
【药物名称】 【化学名称】2-(1-Methylpropylsulfanyl)-6-(1-naphthylmethyl)pyrimidin-4(3H)-one 【CA登记号】 【 分 子 式 】C19H20N2OS 【 分 子 量 】324.44805 |
【开发单位】 【药理作用】 |
合成路线1
Condensation of 4-(1-naphthylmethyl)-3-oxobutanoic acid methyl ester (I) with thiourea (II) followed by alkylation of the thioxo group of compound (III) with sec-butyl iodide (IV) led to the formation of target compound
【1】 Artico, M.; Selected non-nucleoside reverse transcriptase inhibitors (NNRTIs): the DABOs family. Drugs Fut 2002, 27, 2, 159. |
Extended Information