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【结 构 式】

【分子编号】51807

【品名】2-iodobutane; sec-Butyl iodide

【CA登记号】513-48-4

【 分 子 式 】C4H9I

【 分 子 量 】184.01993

【元素组成】C 26.11% H 4.93% I 68.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Condensation of 4-(1-naphthylmethyl)-3-oxobutanoic acid methyl ester (I) with thiourea (II) followed by alkylation of the thioxo group of compound (III) with sec-butyl iodide (IV) led to the formation of target compound

1 Artico, M.; Selected non-nucleoside reverse transcriptase inhibitors (NNRTIs): the DABOs family. Drugs Fut 2002, 27, 2, 159.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 51808 methyl (Z)-3-hydroxy-4-(1-naphthyl)-2-butenoate C15H14O3 详情 详情
(II) 10180 Thiourea 62-56-6 CH4N2S 详情 详情
(III) 51806 6-(1-naphthylmethyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone C15H12N2OS 详情 详情
(IV) 51807 2-iodobutane; sec-Butyl iodide 513-48-4 C4H9I 详情 详情
Extended Information