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【结 构 式】 
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【药物名称】 【化学名称】3exo-(4-Iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2exo-carboxylic acid 2-fluoroethyl ester 【CA登记号】 【 分 子 式 】C17H21FINO2 【 分 子 量 】417.26522 |
【开发单位】McLean Hospital (Originator), Natural Pharmacia (Originator) 【药理作用】Diagnostic Agents, Dopamine Transporter (DAT) Inhibitors |
合成路线1
Conjugate addition of 4-(trimethylsilyl)phenylmagnesium bromide (II) to anhydroecgonine methyl ester (I) afforded regioselectively the 2-beta-carbomethoxy-3-beta-aryl tropane (III). Iododesilylation of (III) using ICl or iodine in the presence of AgBF4 gave the iodophenyl derivative (IV). Hydrolysis of the ester function of (IV) in aqueous dioxan yielded the corresponding acid (V). Treatment of (V) with POCl3 provided the acid chloride (VI), which was finally condensed with 2-fluoroethanol (VII) to yield the title fluoroethyl ester.
| 【1】 Gu, X.-H.; et al.; Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: Potential positron emission tomography (PET) imaging agents for the dopamine transporter. Bioorg Med Chem Lett 2001, 11, 23, 3049. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21118 | methyl (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate | C10H15NO2 | 详情 | 详情 | |
| (II) | 50257 | bromo[4-(trimethylsilyl)phenyl]magnesium | C9H13BrMgSi | 详情 | 详情 | |
| (III) | 50258 | methyl (1R,2S,3S,5S)-8-methyl-3-[4-(trimethylsilyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate | C19H29NO2Si | 详情 | 详情 | |
| (IV) | 50259 | methyl (1R,2S,3S,5S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate | C16H20INO2 | 详情 | 详情 | |
| (V) | 50260 | (1R,2S,3S,5S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid | C15H18INO2 | 详情 | 详情 | |
| (VI) | 50261 | (1R,2S,3S,5S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carbonyl chloride | C15H17ClINO | 详情 | 详情 | |
| (VII) | 44106 | 2-fluoro-1-ethanol | 371-62-0 | C2H5FO | 详情 | 详情 |