合成路线1

Conjugate addition of 4-(trimethylsilyl)phenylmagnesium bromide (II) to anhydroecgonine methyl ester (I) afforded regioselectively the 2-beta-carbomethoxy-3-beta-aryl tropane (III). Iododesilylation of (III) using ICl or iodine in the presence of AgBF4 gave the iodophenyl derivative (IV). Hydrolysis of the ester function of (IV) in aqueous dioxan yielded the corresponding acid (V). Treatment of (V) with POCl3 provided the acid chloride (VI), which was condensed with 1,3-propanediol monomesylate (VII) to yield ester (VIII). Finally, nucleophilic displacement of the mesylate group of (VIII) with tetrabutylammonium fluoride in refluxing THF afforded the title fluoropropyl ester.