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【结 构 式】 
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【药物名称】VN-2142 【化学名称】1-(2-Methoxyphenyl)-4-[3-(1-naphthyloxy)-3-(3-thienyl)propyl]piperazine hydrochloride 【CA登记号】 【 分 子 式 】C28H31ClN2O2S 【 分 子 量 】495.08847 |
【开发单位】Universidad de Navarra (Originator), Vita (Originator) 【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, 5-HT Reuptake Inhibitors, 5-HT1A Antagonists |
合成路线1
Mannich reaction of N-(2-methoxyphenyl)piperazine (I) with 3-acetylthiophene (II) in the presence of paraformaldehyde and HCl in refluxing EtOH leads to the piperazinyl propanone (III). Subsequent keto group reduction with NaBH4 gives alcohol (IV). This is then condensed with 1-fluoronaphthalene (V) in the presence of NaH to produce the title naphthyl ether.
| 【1】 Oficialdegui, A.-M.; Martínez-Esparza, J.; Pérez-Sailanes, S.; et al.; New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. J Med Chem 2001, 44, 3, 418. |
| 【2】 Bosch Rovira, A.; Roca Acin, J.; Monge Vega, A.; Del Rio Zambrana, J.; Palop Cubillo, J.A.; Lasheras Aldaz, B.; Del Castillo Nieto, J.C. (Laboratorios Vita, SA); Cpds. derived from thiophene and benzothiophene, and related utilisation and compsn.. EP 1008594; ES 2128266; JP 2002511883; US 6262056; WO 9902516 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11882 | 1-(2-Methoxyphenyl)piperazine; Methyl 2-piperazinophenyl ether; 1-(2-Methoxyphenyl)-piperazine | 35386-24-4 | C11H16N2O | 详情 | 详情 |
| (II) | 34619 | 1-(3-thienyl)-1-ethanone | 1468-83-3 | C6H6OS | 详情 | 详情 |
| (III) | 57497 | 3-[4-(2-methoxyphenyl)-1-piperazinyl]-1-(3-thienyl)-1-propanone | C18H22N2O2S | 详情 | 详情 | |
| (IV) | 57498 | 3-[4-(2-methoxyphenyl)-1-piperazinyl]-1-(3-thienyl)-1-propanol | C18H24N2O2S | 详情 | 详情 | |
| (V) | 40503 | 1-fluoronaphthalene | 321-38-0 | C10H7F | 详情 | 详情 |
Extended Information