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【结 构 式】 
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【药物名称】SB-357134 【化学名称】N-(2,5-Dibromo-3-fluorophenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide 【CA登记号】219963-52-7 【 分 子 式 】C17H18Br2FN3O3S 【 分 子 量 】523.22171 |
【开发单位】GlaxoSmithKline (Originator) 【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, 5-HT6 Antagonists |
合成路线1
1-(2-Methoxyphenyl)-4-trichloroacetylpiperazine (II), prepared from 1-(2-methoxyphenyl)piperazine (I) and trichloroacetyl chloride, was treated with chlorosulfonic acid to give the sulfonyl chloride (III). Coupling of chloride (III) with 2,5-dibromo-3-fluoroaniline (IV) afforded sulfonamide (IV). Finally, removal of the trichloroacetyl protecting group under basic conditions provided the title piperazine derivative.
| 【2】 Moss, S.F.; Bromidge, S.M. (SmithKline Beecham plc); Novel cpds.. WO 9902502 . |
| 【1】 Bromidge, S.M.; Gager, T.; Clarke, S.E.; et al.; Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: Identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134). Bioorg Med Chem Lett 2001, 11, 1, 55. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11882 | 1-(2-Methoxyphenyl)piperazine; Methyl 2-piperazinophenyl ether; 1-(2-Methoxyphenyl)-piperazine | 35386-24-4 | C11H16N2O | 详情 | 详情 |
| (II) | 48007 | 2,2,2-trichloro-1-[4-(2-methoxyphenyl)-1-piperazinyl]-1-ethanone | C13H15Cl3N2O2 | 详情 | 详情 | |
| (III) | 48008 | 4-methoxy-3-[4-(2,2,2-trichloroacetyl)-1-piperazinyl]benzenesulfonyl chloride | C13H14Cl4N2O4S | 详情 | 详情 | |
| (IV) | 48009 | 2,5-dibromo-3-fluoroaniline; 2,5-dibromo-3-fluorophenylamine | C6H4Br2FN | 详情 | 详情 | |
| (V) | 48010 | N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-[4-(2,2,2-trichloroacetyl)-1-piperazinyl]benzenesulfonamide | C19H17Br2Cl3FN3O4S | 详情 | 详情 |
Extended Information