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【结 构 式】 
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【药物名称】 【化学名称】1-(4-Benzyl-2-cyclohexyloxazol-5-ylmethyl)-4-(2-methoxyphenyl)piperazine 【CA登记号】 【 分 子 式 】C28H35N3O2 【 分 子 量 】445.61005 |
【开发单位】Wyeth Pharmaceuticals (Originator) 【药理作用】Antidepressants, Anxiolytics, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, 5-HT1A Receptor Agonists |
合成路线1
Coupling of piperazine (I) with chloro derivative (II) by means of K2CO3 and KI in acetone affords protected compound (III), which is then condensed with acid chloride (IV) by means of n-BuLi in THF to yield amide (V). Deprotection of (V) by hydrogenation over Pd/C in EtOH provides (VI), which is finally cyclized by treatment with POCl3 in DMF. Alternatively, the synthesis of the target product can be achieved by an analogous route: Acylation of amine (VII) with acid chloride (IV) by means of K2CO3 in CH2Cl2 provides amide (VIII), which is then cyclized by heating with POCl3 in DMF/benzene to give oxazole (IX). Finally, (IX) is condensed with piperazine (I) by means of K2CO3 and KI in acetone.
| 【1】 Schechter, L.E.; Smith, D.L.; Nelson, F.C.; Greenblatt, L.P.; Kelly, M.G.; Novel trisubstituted oxazole derivatives as 5-HT1A receptor ligands. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 117. |
| 【2】 Kelly, M.G.; Greenblatt, L.P.; Nelson, F.C. (American Home Products Corp.); Trisubstd. oxazole derivs. as serotonin ligands. US 6242448 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11882 | 1-(2-Methoxyphenyl)piperazine; Methyl 2-piperazinophenyl ether; 1-(2-Methoxyphenyl)-piperazine | 35386-24-4 | C11H16N2O | 详情 | 详情 |
| (II) | 37926 | benzyl (1S)-1-benzyl-3-chloro-2-oxopropylcarbamate | 26049-94-5 | C18H18ClNO3 | 详情 | 详情 |
| (III) | 46228 | benzyl 1-benzyl-3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-oxopropylcarbamate | C29H33N3O4 | 详情 | 详情 | |
| (IV) | 17220 | cyclohexanecarbonyl chloride; Cyclohexanecarboxylic acid chloride | 2719-27-9 | C7H11ClO | 详情 | 详情 |
| (V) | 46229 | benzyl 1-benzyl-3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-oxopropyl(cyclohexylcarbonyl)carbamate | C36H43N3O5 | 详情 | 详情 | |
| (VI) | 46230 | N-[1-benzyl-3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-oxopropyl]cyclohexanecarboxamide | C28H37N3O3 | 详情 | 详情 | |
| (VII) | 46231 | 3-amino-1-chloro-4-phenyl-2-butanone | C10H12ClNO | 详情 | 详情 | |
| (VIII) | 46232 | N-(1-benzyl-3-chloro-2-oxopropyl)cyclohexanecarboxamide | C17H22ClNO2 | 详情 | 详情 | |
| (IX) | 46233 | 4-benzyl-5-(chloromethyl)-2-cyclohexyl-1,3-oxazole | C17H20ClNO | 详情 | 详情 |