|
【结 构 式】 
|
【药物名称】Etravirine, TMC-125, R-165335, Intelence 【化学名称】4-[6-Amino-5-bromo-2-(4-cyanophenylamino)pyrimidin-4-yloxy]-3,5-dimethylbenzonitrile 【CA登记号】269055-15-4 【 分 子 式 】C20H15BrN6O 【 分 子 量 】435.28615 |
【开发单位】Janssen (Originator), Tibotec-Virco (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Reverse Transcriptase Inhibitors |
合成路线1
The reaction of 5-bromo-2,4,6-trichloropyrimidine (I) with 4-aminobenzonitrile (II) by means of DIEA in refluxing dioxane gives the diarylamine (III), which is condensed with 4-hydroxy-3,5-dimethylbenzonitrile (IV) by means of NaH in NMP to yield the corresponding adduct (V). Finally, this compound is treated with ammonia in dioxane at 150 C in a pressure vessel.
| 【1】 Heeres, J.; De Corte, B.; Kukla, M.J.; Van Aken, K.J.A.; Janssen, P.A.J.; Ludovici, D.W.; De Jonge, M.R.; Kavash, R.W.; Ho, C.Y.; Koymans, L.M.H. (Janssen Pharmaceutica NV); HIV replication inhibiting pyrimidines. EP 1002795; WO 0027825 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 46616 | 5-bromo-2,4,6-trichloropyrimidine | C4BrCl3N2 | 详情 | 详情 | |
| (II) | 15361 | 4-Aminobenzonitrile | 873-74-5 | C7H6N2 | 详情 | 详情 |
| (III) | 46617 | 4-[(5-bromo-4,6-dichloro-2-pyrimidinyl)amino]benzonitrile | C11H5BrCl2N4 | 详情 | 详情 | |
| (IV) | 31141 | 4-Hydroxy-3,5-dimethylbenzonitrile; 2,6-Dimethyl-4-hydroxybenzonitrile | 4198-90-7 | C9H9NO | 详情 | 详情 |
| (V) | 46618 | 4-[[5-bromo-6-chloro-2-(4-cyanoanilino)-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile | C20H13BrClN5O | 详情 | 详情 |
合成路线2
The cyclization of 4-guanidinobenzonitrile (I) with diethyl malonate (II) by means of NaOEt in ethanol gives 4-(4,6-dihydroxypyrimidin-2-ylamino)benzonitrile (III), which is treated with POCl3 to yield the corresponding dichloro derivative (IV). The bromination of (IV) with Br2 and NaHCO3 in methanol/water affords 4-(5-bromo-4,6-dichloropyrimidin-2-ylamino)benzonitrile (V), which is condensed with sodium 4-cyano-2,6-dimethylphenolate (VI) and N-methylpyrrolidone in dioxane to provide the chloro precursor (VII). Finally, this compound is treated with ammonia in isopropanol to yield the target dinitrile derivative.
| 【1】 Ludovici, D.W.; De Corte, B.L.; Kukla, M.J.; et al.; Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues. Bioorg Med Chem Lett 2001, 11, 17, 2235. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 55735 | N-(4-cyanophenyl)guanidine | C8H8N4 | 详情 | 详情 | |
| (II) | 16829 | Diethyl malonate | 105-53-3 | C7H12O4 | 详情 | 详情 |
| (III) | 55736 | 4-[(4,6-dihydroxy-2-pyrimidinyl)amino]benzonitrile | C11H8N4O2 | 详情 | 详情 | |
| (IV) | 55737 | 4-[(4,6-dichloro-2-pyrimidinyl)amino]benzonitrile | C11H6Cl2N4 | 详情 | 详情 | |
| (V) | 46617 | 4-[(5-bromo-4,6-dichloro-2-pyrimidinyl)amino]benzonitrile | C11H5BrCl2N4 | 详情 | 详情 | |
| (VI) | 55738 | sodium 4-cyano-2,6-dimethylbenzenolate | C9H8NNaO | 详情 | 详情 | |
| (VII) | 55739 | ethyl 1-(2-{[(1S)-1-phenylethyl]amino}acetyl)cyclopropanecarboxylate | C16H21NO3 | 详情 | 详情 |
合成路线3
| 【1】 Shashikant J, Golak CM, Shyam T, et al. 2010. An improved synthesis of etravirine. Orangic Process Research & Development, 14: 657～660. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43734 | 2,4,6-trichloropyrimidine | 3764-01-0 | C4HCl3N2 | 详情 | 详情 |
| (II) | 31141 | 4-Hydroxy-3,5-dimethylbenzonitrile; 2,6-Dimethyl-4-hydroxybenzonitrile | 4198-90-7 | C9H9NO | 详情 | 详情 |
| (III) | 67127 | 4-((2,6-dichloropyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile | 4198-90-7 | C13H9Cl2N3O | 详情 | 详情 |
| (IV) | 15361 | 4-Aminobenzonitrile | 873-74-5 | C7H6N2 | 详情 | 详情 |
| (V) | 67128 | 4-((4-(4-(aminomethyl)-2,6-dimethylphenoxy)-6-chloropyrimidin-2-yl)amino)benzonitrile | C20H14ClN5O | 详情 | 详情 | |
| (VI) | 67129 | 4-((6-((4-(aminomethyl)phenyl)amino)-2-chloropyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile | C20H14ClN5O | 详情 | 详情 |