【结 构 式】 |
【药物名称】PNU-177496 【化学名称】2-[4-[2(S)-[3-[1(S)-Carboxy-2-phenylethyl]ureido]-2-(N-pentylcarbamoyl)ethyl]phenoxy]malonic acid 【CA登记号】221076-63-7 【 分 子 式 】C27H33N3O9 【 分 子 量 】543.57876 |
【开发单位】Pfizer (Originator) 【药理作用】Antidiabetic Drugs, ENDOCRINE DRUGS, Type 2 Diabetes Mellitus, Agents for, Insulin Sensitizers, Protein Tyrosine Phosphatase PTP-1B Inhibitors |
合成路线1
Coupling of N-Cbz-tyrosine (I) with n-pentylamine (II) afforded amide (III). Subsequent alkylation of the phenol group of (III) with diethyl chloromalonate (IV) gave phenoxy malonate (V). Hydrogenolytical deprotection of the N-Cbz group of (V) provided the corresponding amine, which was isolated as the hydrochloride salt (VI). Conversion of (VI) to isocyanate (VII) was effected by treatment with diphosgene in the presence of Proton Sponge(r). Addition of phenylalanine ethyl ester (VIII) to isocyanate (VII) furnished urea (IX). Finally, the ethyl ester groups of (IX) were saponified with LiOH to yield the title compound.
【1】 Bleasdale, J.; May, P.D.; Schostarez, H.J.; Barf, T.; Larsen, S.D.; Liljebris, C. (Pharmacia Corp.); Inhibitors of protein tyrosine phosphatase. WO 9911606 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 39328 | (2S)-2-[[(benzyloxy)carbonyl]amino]-3-(4-hydroxyphenyl)propionic acid | C17H17NO5 | 详情 | 详情 | |
(II) | 15764 | amylamine; 1-pentanamine; pentylamine | 110-58-7 | C5H13N | 详情 | 详情 |
(III) | 39329 | benzyl (1S)-1-(4-hydroxybenzyl)-2-oxo-2-(pentylamino)ethylcarbamate | C22H28N2O4 | 详情 | 详情 | |
(IV) | 39330 | diethyl 2-chloromalonate | 14064-10-9 | C7H11ClO4 | 详情 | 详情 |
(V) | 39331 | diethyl 2-[4-[(2S)-2-[[(benzyloxy)carbonyl]amino]-3-oxo-3-(pentylamino)propyl]phenoxy]malonate | C29H38N2O8 | 详情 | 详情 | |
(VI) | 39332 | diethyl 2-[4-[(2S)-2-amino-3-oxo-3-(pentylamino)propyl]phenoxy]malonate | C21H32N2O6 | 详情 | 详情 | |
(VII) | 39333 | diethyl 2-[4-[(2S)-2-isocyanato-3-oxo-3-(pentylamino)propyl]phenoxy]malonate | C22H30N2O7 | 详情 | 详情 | |
(VIII) | 32593 | ethyl (2S)-2-amino-3-phenylpropanoate | C11H15NO2 | 详情 | 详情 | |
(IX) | 39334 | diethyl 2-[4-[(2S)-2-[([[(1S)-1-benzyl-2-ethoxy-2-oxoethyl]amino]carbonyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy]malonate | C33H45N3O9 | 详情 | 详情 |